Biomarkers in Cancer Screening and Early Detection

Description

Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment.

Key Features

• Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers
• Provides immediately actionable information and hopefully also inspiration to move discovery and clinical application forward
• Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers

Table of Contents

1. List of Contributors, ix
2. Preface, xiii
3. Part I Foundations of Biomarker Research
   1. Nuts and Bolts of Biomarker Research, 3 – Sharmistha Ghosh and Sudhir Srivastava
   2. Cancer Genome Methylation: Biology, Biomarker and Therapeutic Opportunities, 16 – Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi
   3. MicroRNA Biomarkers for Early Detection of Cancer, 27 – WendyWang, Matthew R Young, and Sudhir Srivastava
   4. Inflammation and Cancer, 37 – Pamela L Beatty, Sandra Cascio, and Olivera J Finn
   5. Exosomes: A Valuable Biomedical Tool in Biomarker Discovery and Development, 50 – Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava
   6. Epithelial-to-Mesenchymal Transition (EMT): Clinical Implications, 64 – Elisa CWoodhouse and Suresh Mohla
4. Part II State-of-the-Science in Organ-Specific Biomarker Research
   1. Breast Cancer, 77 – Benjamin A Katchman, Christos Patriotis, and Karen S Anderson
   2. Ovarian Cancer, 93 – Christos Patriotis, Archana Simmons, Karen H Lu, Robert C Bast, Jr, and Steven J Skates
   3. Esophageal Cancer Biomarkers, 104 – Yanxin Luo, Kishore Guda, SanfordD Markowitz, Amitabh Chak, Andrew M Kaz, andWilliam M Grady
   4. Predictive Biomarkers for Therapy in Adenocarcinoma of the Upper Digestive Tract, 118 – Heath D Skinner, Qiongrong Chen, Elena Elimova, RoopmaWadhwa, Shumei Song, and Jaffer A Ajani
   5. Pancreatic Cancer, 130 – Sam CWang and Peter J Allen
   6. Colon Cancer, 141 – Paul DWagner
   7. Prognostic and Predictive Biomarkers for Colorectal Cancer, 151 – Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava
   8. Early Detection of Lung Cancer, 163 – Mohamed Hassanein, Melinda C Aldrich, Stephen A Deppen, Karl E Krueger, Eric L Grogan, and Pierre P Massion
   9. Commonalities in Lung Cancer and COPD, 185 – MalgorzataWojtowicz and Eva Szabo
   10. Prostate Cancer, 197 – Jacob Kagan, Ian M Thompson, and DanielWChan
5. Part III Biomarkers, Screening and Precision Health: Implications for Public Health
   1. Improving the Clinical Validity of Biomarker Research in Cancer Detection, 209 – David F Ransohoff
   2. Cancer Overdiagnosis, Ramifications and Research Strategies, 220 – Barbara K Dunn and Barnett S Kramer
   3. Predictive Markers and Driver Genes From Treatment Trials: Potential Utility For Early Diagnosis, 231 – Brian S Sorg, Sarfraz Memon, Kelly Y Kim, Aniruddha Ganguly, Tracy Lively, James Tricoli, Magdalena Thurin, Lokesh Agrawal, Tawnya C McKee, Barbara A Conley, and J Milburn Jessup
   4. Statistical Consideration in Predictive and Prognostic Markers, 245 – Fei Ye and Yu Shyr
   5. Clinical Validation of Molecular Biomarkers in Translational Medicine, 256 – Harry B Burke and William E Grizzle
   6. Cancer Biomarker Assays: Performance Standards, 267 – Anna K Fuzery and Daniel W Chan
   7. Bioethics and Cancer Biomarker Research, 277 – Nathan Nobis, William Grizzle, and Stephen Sodeke
   8. Colon Cancer Screening, 283 – Molly Perencevich, Jennifer Inra, and Sapna Syngal

Editors Biography

Sudhir Srivastava, Ph.D., MPH Senior Scientific Officer, Chief, Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Robert C. Bast, MD, Vice President for Translational Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Maurie Markman, MD, Senior Vice President for Clinical Affairs, Cancer Treatment Centers of America, Clinical Professor of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA

Ernest Hawk, MD, MPH, Vice President, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA