Cardiac Electrophysiology: From Cell To Bedside (7th Edition)

Description

Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field.

Key Features

• All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics.
• New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations).
• Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online.
• New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text.
• Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Table of Contents

1. Section 1 Structural and Molecular Bases of Ion Channel Function
   1. Voltage-Gated Sodium Channels and Electrical Excitability of the Heart
   2. Voltage-Gated Calcium
   3. Voltage-Gated Potassium Channels
   4. Structural and Molecular Bases of Cardiac Inward Rectifier Potassium Channel Function
   5. Mammalian Calcium Pumps in Health and Disease
   6. Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function
   7. Organellar Ion Channels and Transporters
   8. Molecular Organization, Gating and Function of Connexin-based Gap Junction Channels and Hemichannels
2. Section 2 Biophysics of Cardiac Ion Channel Function
   1. Structure-function relations of Heterotrimetric complexes of sodium channel a and ss subunits
   2. Regulation of Cardiac Calcium Channels
   3. Inhibition of Phosphoinositide 3-Kinase and Acquired Long QT Syndrome
   4. Structural Determinants and Biophysical Properties of hERG1 Channel Gating
   5. Molecular Regulation of Cardiac Inward Rectifier Potassium Channels by Pharmacological Agents
   6. Cardiac Stretch-Activated Channels and Mechano-Electric Coupling
   7. Biophysical Properties of Gap Junctions
   8. Excitation-Contraction Coupling
3. Section 3 Intermolecular Interactions and Cardiomyocyte Electrical Function
   1. Ion Channel Trafficking in the Heart
   2. Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5
   3. Fibroblast growth factor homologous factors modulate cardiac calcium channels.
   4. Macromolecular Complexes and Cardiac Potassium Channels
   5. Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias
   6. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion and cell excitability
   7. Function and dysfunction of ion channel membrane trafficking and post translational modification
   8. Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling.
4. Section 4 Cell Biology of Cardiac Impulse Initiation and Propagation
   1. Stem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: insights from sinoatrial node development and function.
   2. Gene Therapy and Biological Pacing
   3. Intercellular Communication and Impulse Propagation
   4. Mechanisms of normal and dysfunctional Sinoatrial Nodal Excitability and Propagation
   5. Cell Biology of the Specialized Cardiac Conduction System
   6. Cardiac Remodeling and Regeneration
5. Section 5 Models of Cardiac Excitation
   1. Ionic Mechanisms of Atrial Action Potentials
   2. Genetic algorithms to generate dynamical complexity electrophysiological models
   3. Calcium Signaling in Cardiomyocyte Models with Realistic Geometries
   4. Theory of Rotors and Arrhythmias
   5. Computational approaches for Accurate Rotor localization in the Human Atria
   6. Modeling the aging heart
6. Section 6 Neural Control of Cardiac Electrical Activity
   1. Innervation of the sinoatrial node
   2. Mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.
   3. Pulmonary Vein Ganglia and the Neural Regulation of the Heart Rate
   4. Neural Activity and Atrial Tachyarrhythmias
   5. Sympathetic Innervation and Cardiac Arrhythmias
7. Section 7 Arrhythmia Mechanisms
   1. The Molecular Pathophysiology of Atrial Fibrillation
   2. Myofibroblasts, Cytokines, and Persistent Atrial Fibrillation
   3. Role of the Autonomic Nervous System in Atrial Fibrillation
   4. Rotors in Human Atrial Fibrillation
   5. Body surface frequency-phase mapping of atrial fibrillation.
   6. Panoramic Mapping of Atrial Fibrillation from the body surface
   7. Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation
   8. Genetics of Atrial Fibrillation
8. Section 8 Molecular Genetics and Pharmacogenomics
   1. Mechanisms in Heritable Sodium Channel Diseases
   2. Genetic, Ionic and Cellular Mechanisms Underlying the J Wave Syndromes
   3. Inheritable Potassium Channel Diseases
   4. Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation
9. Section 9 Pharmacologic, Genetic and Cell Therapy of Ion Channel Dysfunction
   1. Pharmacologic Bases of Antiarrhythmic Therapy
   2. Pharmacogenomics of Cardiac Arrhythmias
   3. Gene therapy to treat cardiac arrhythmias
   4. Highly Mature Human iPSC-Derived Cardiomyocytes as Models for Cardiac Electrophysiology and Drug Testing
   5. Cardiac repair with human induced pluripotent stem cell-derived cardiovascular cells.
10. Section 10 DIAGNOSTIC EVALUATION
    1. Assessment of the patient with a cardiac arrhythmia
    2. Electrocardiography of tachyarrhythmias: Differential diagnosis of narrow and wide QRS complex tachycardias
    3. Electroanatomic Mapping for arrhythmias
    4. Computed tomography for electrophysiology
    5. Magnetic resonance imaging for electrophysiology
    6. Intracardiac echocardiography for electrophysiology
    7. Exercise-induced arrhythmias
    8. Cardiac monitoring: short- and long-term recording
    9. Head-up Tilt Table Testing
    10. Autonomic Regulation and Cardiac Risk
    11. T-wave alternans
    12. Noninvasive Electrocardiographic Imaging of Human Ventricular Arrhythmias and Electrophysiological Substrate
    13. Genetic testing
11. Section 11 SUPRAVENTRICULAR TACHYARRHYTHIAS: MECHANISMS, CLINICAL FEATURES, AND MANAGEMENT
    1. Sinus node abnormalities
    2. Atrial tachycardia
    3. Atrial tachycardia in adults with congenital heart disease
    4. Typical and Atypical Atrial Flutter: Mapping and Ablation
    5. Atrial fibrillation
    6. Preexcitation, Atrioventricular reentry, Variants
    7. Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Rentrant Circuits
    8. Junctional tachycardia
12. Section 12 VENTRICULAR TACHYCARRHYTHMIAS: MECHANISMS, CLNICAL FEATURES, AND MANAGEMENT
    1. Premature ventricular complexes
    2. Outflow tract ventricular tachycardias: Mechanisms, Clinical Features, and Management
    3. Fascicular ventricular arrhythmias
    4. Bundle branch reentry tachycardia
    5. Ischemic heart disease
    6. Ventricular Tachycardia in Patients with Dilated Cardiomyopathy
    7. Ventricular Arrhythmias in Hypertrophic Cardiomyopathy
    8. Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
    9. VTs in Catcholaminergic Cardiomyopathy (Catecholaminergic polymorphic ventricular tachycardia)
    10. Ventricular Arrhythmias in Heart failure
    11. Arrhythmias and conduction disturbances in Non Compaction Cardiomyopathy
    12. Takotsubo cardiomyopathy
    13. Brugada syndrome
    14. Long and short QT syndromes
    15. Anderson-Tawil syndrome
    16. Timothy syndrome
    17. J Wave Syndromes
    18. Idiopathic ventricular fibrillation
    19. Sudden infant death syndrome
    20. Sudden cardiac arrest/death in adults
    21. Neurologic disorders
    22. Drug-Induced Ventricular Tachycardia
    23. Ventricular Arrhythmias in Congenital Heart Disease
    24. Section 13 SYNCOPE and Bradyarrhythmias
    25. Syncope
    26. Postural orthostatic tachycardia syndrome
    27. Progressive conduction system disease
    28. Atrioventricular block
    29. Section 14 ARRHYTHMIAS IN SPECIAL POPULATIONS PHARMACOLOGIC THERAPY
    30. Sex differences in arrhythmias
    31. Sudden cardiac death in athletes, inlcuding commotio cordis
    32. Pediatric populations
    33. Sleep-disordered breathing and arrhythmias
    34. Ventricular Assist devices and Cardiac Transplantation Recipients
13. Section 15 PHARMACOLOGIC THERAPY
    1. Standard antiarrhythmic drugs
    2. Innovations In Antiarrhythmic Drug Therapy
    3. Nontraditional drugs for sudden cardiac death
    4. Prevention of stroke in atrial fibrillation: warfarin, anti-factor Xa and thrombin drugs
14. Section 16 CARDIAC IMPLANTABLE ELECTRONIC DEVICES
    1. Implantable cardioverter defibrillators: technical aspects
    2. Implantable cardioverter defibrillators: clinical aspects
    3. Subcutaneous implantable defibrillator
    4. Implantable pacemakers
    5. Cardiac resynchronization therapy
    6. Newer applications of pacemakers
    7. Remote monitoring
15. Section 17 CATHETER ABLATION
    1. Catheter Ablation: Technical aspects
    2. Catheter Ablation: Clinical aspects
    3. Ablation for Atrial fibrillation
    4. Ablation of Supraventricular tachycardias
    5. Catheter Abliation for Ventricular tachycardias with/without structural heart disease
    6. Epicardial and other approaches
    7. Ventricular fibrillation
    8. Ablation in Pediatrics
    9. Congenital heart disease
    10. Anesthesiology for EP procedures
16. Section 18: SURGERY FOR ARRHYTHMIAS
    1. Surgery for Atrial fibrillation and other supraventricular tachycardias
    2. Surgery for Ventricular tachycardia
17. Section 19 NEW APPROACHES
    1. Cervical vagal stimulation for heart failure
    2. Baroreflex stimulation
    3. Spinal cord stimulation for heart failure and Arrhythmias
    4. Renal artery denervation
    5. Left atrial appendage occlusion/ligation

Authors Biography

Douglas Zipes

Affiliations and Expertise

Distinguished Professor, Division of Cardiology and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana

Jose Jalife
Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.

Affiliations and Expertise

Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.

William Stevenson
Dr Jalife is also actively conducting research at the Centro Nacional de Investigaciones Cardiovasculares, in Madrid, Spain. William Gregory Stevenson, MD, is Professor of Medicine at Vanderbilt University School of Medicine in Nashville, Tennessee. Dr Jalife will assume the role of lead editor on the 8th edition with Douglas Zipes’s retirement

Affiliations and Expertise

Director, Cardiac Arrhythmia Program, Cardiovascular Division, Brigham and Women’s Hospital; Professor of Medicine Harvard Medical School, Boston, MA