Comprehensive Clinical Nephrology (6th Edition)

Description

Written and edited by world leaders in nephrology, Comprehensive Clinical Nephrology, 6th Edition, by Drs. John Feehally, Jurgen Floege, Richard J. Johnson, and Marcello Tonelli, provides current information on clinical procedures and conditions as well as the scientific facts and pathophysiology that are foundational to nephrology practice. Ideal for practicing nephrologists, fellows, residents, and internists, it thoroughly covers fluids and electrolytes, hypertension, diabetes, dialysis, and transplantation, and more – all in a single convenient volume.

Key Features

• Popular, color-coded algorithms provide easy access to key content: yellow boxes for general information, green boxes for therapeutic intervention, and blue boxes for necessary investigations.
• A “just right” amount of basic science and practical clinical guidance helps you make efficient and informed decisions.
• More than 1,500 full-color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management.

New to this Edition

• New quick-reference boxes with links to clinical guidelines in all relevant chapters.
• New chapters on common issues regarding prescribing in kidney disease, palliative nephrology, endemic nephropathies, pathophysiology of chronic kidney disease, and outcomes of dialysis.
• Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Table of Contents

1. SECTION I Essential Renal Anatomy and Physiology
   1. Renal Anatomy, 1
   2. Renal Physiology, 14
2. SECTION II Investigation of Renal Disease
   1. Assessment of Glomerular Filtration Rate, 29
   2. Urinalysis, 39
   3. Imaging, 53
   4. Renal Biopsy, 72
3. SECTION III Fluid and Electrolyte Disorders
   1. Disorders of Extracellular Volume, 80
   2. Disorders of Water Metabolism, 94
   3. Disorders of Potassium Metabolism, 111
   4. Disorders of Calcium, Phosphate, and Magnesium Metabolism, 124
   5. Normal Acid-Base Balance, 142
   6. Metabolic Acidosis, 149
   7. Metabolic Alkalosis, 160
   8. Respiratory Acidosis, Respiratory Alkalosis, and Mixed Disorders, 170
4. SECTION IV Glomerular Disease
   1. Introduction to Glomerular Disease: Clinical Presentations, 184
   2. Introduction to Glomerular Disease: Histologic Classification and Pathogenesis, 199
   3. Minimal Change Disease, 209
   4. Primary and Secondary (Non-Genetic) Causes of Focal and Segmental Glomerulosclerosis, 219
   5. Inherited Causes of Nephrotic Syndrome, 232
   6. Membranous Nephropathy, 240
   7. Membranoproliferative Glomerulonephritis and Cryoglobulinemic Glomerulonephritis, 254
   8. Glomerulonephritis Associated With Complement Disorders, 263
   9. Immunoglobulin A Nephropathy and IgA Vasculitis (Henoch-Schönlein Purpura), 270
   10. Anti–Glomerular Basement Membrane Disease and Goodpasture Disease, 281
   11. Renal and Systemic Vasculitis, 290
   12. Lupus Nephritis, 306
   13. Renal Amyloidosis and Glomerular Diseases With Monoclonal Immunoglobulin Deposition, 320
   14. Rare Glomerular Disorders, 333
   15. Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome, 343
5. SECTION V Diabetic Kidney Disease
   1. Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease, 357
   2. Prevention and Treatment of Diabetic Kidney Disease, 376
   3. Management of the Diabetic Patient With Chronic Kidney Disease, 385
6. SECTION VI Hypertension
   1. Normal Blood Pressure Control and the Evaluation of Hypertension, 396
   2. Primary Hypertension, 412
   3. Nonpharmacologic Prevention and Treatment of Hypertension, 422
   4. Pharmacologic Treatment of Hypertension, 430
   5. Evaluation and Treatment of Hypertensive Emergencies and Urgencies, 444
   6. Endocrine Causes of Hypertension: Aldosterone, 453
   7. Other Endocrine Causes of Hypertension, 463
   8. Neurogenic Hypertension, Including Hypertension Associated With Stroke or Spinal Cord Injury, 473
7. SECTION VII Renovascular Disease
   1. Renovascular Hypertension and Ischemic
   2. Nephropathy, 482
8. SECTION VIII Pregnancy and Renal Disease
   1. Renal Physiology and Complications in Normal Pregnancy, 502
   2. Pregnancy With Preexisting Kidney Disease, 522
9. SECTION IX Hereditary and Congenital Diseases of the Kidney
   1. Autosomal Dominant Polycystic Kidney Disease, 532
   2. Other Cystic Kidney Diseases, 545
   3. Alport Syndrome and Other Familial Glomerular Syndromes, 560
   4. Inherited Disorders of Sodium and Water Handling, 575
   5. Fanconi Syndrome and Other Proximal Tubule Disorders, 586
   6. Sickle Cell Diseases and the Kidney, 597
   7. Congenital Anomalies of the Kidney and Urinary Tract, 607
10. SECTION X Infectious Diseases and the Kidney
    1. Urinary Tract Infections in Adults, 626
    2. Tuberculosis of the Urinary Tract, 639
    3. Fungal Infections of the Urinary Tract, 650
    4. The Kidney in Schistosomiasis, 655
    5. Glomerular Diseases Associated With Infection, 664
    6. Human Immunodeficiency Virus Infection and the Kidney, 679
11. SECTION XI Urologic Disorders
    1. Nephrolithiasis and Nephrocalcinosis, 689
    2. Urinary Tract Obstruction, 704
    3. Urologic Issues for the Nephrologist, 717
12. SECTION XII Tubulointerstitial and Vascular Diseases
    1. Acute Interstitial Nephritis, 729
    2. Primary Vesicoureteral Reflux and Reflux Nephropathy, 738
    3. Chronic Interstitial Nephritis, 748
    4. Endemic Nephropathies, 761
    5. Myeloma and the Kidney, 767
13. SECTION XIII Renal Disease and Cancer
    1. Onconephrology: Kidney Disease in Cancer Patients, 776
14. SECTION XIV Acute Kidney Injury
    1. Pathophysiology and Etiology of Acute Kidney Injury, 786
    2. Acute Kidney Injury in the Tropics, 802
    3. Diagnosis and Clinical Evaluation of Acute Kidney Injury, 810
    4. Epidemiology and Prognostic Impact of Acute Kidney Injury, 820
    5. Prevention and Nondialytic Management of Acute Kidney Injury, 825
    6. Dialytic Management of Acute Kidney Injury and Intensive Care Unit Nephrology, 838
    7. Dialytic Management of Refractory Heart Failure, 852
    8. Hepatorenal Syndrome, 859
15. SECTION XV Drug Therapy in Kidney Disease
    1. Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Renal Replacement Therapy, 870
    2. Common Issues in Prescribing in Kidney Disease and Renal Replacement Therapy, 880
    3. Herbal and Over-the-Counter Medicines and the Kidney, 894
16. SECTION XVI Chronic Kidney Disease and the Uremic Syndrome
    1. Epidemiology of Chronic Kidney Disease and Dialysis, 903
    2. Pathophysiology of Disease Progression in Proteinuric and Nonproteinuric Kidney Disease, 913
    3. Retarding Progression of Kidney Disease, 924
    4. Clinical Evaluation and Management of Chronic Kidney Disease, 935
    5. Cardiovascular Disease in Chronic Kidney Disease, 942
    6. Anemia in Chronic Kidney Disease, 958
    7. Other Blood and Immune Disorders in Chronic Kidney Disease, 967
    8. Bone and Mineral Disorders in Chronic Kidney Disease, 979
    9. Neurologic Complications of Chronic Kidney Disease, 996
    10. Gastroenterology and Nutrition in Chronic Kidney Disease, 1002
    11. Dermatologic Manifestations of Chronic Kidney Disease, 1013
    12. Acquired Cystic Kidney Disease and Malignant Neoplasms, 1022
17. SECTION XVII Geriatric and Palliative Nephrology
    1. Geriatric Nephrology, 1028
18. SECTION XVIII Dialytic Therapies
    1. Approach to Renal Replacement Therapy, 1036
    2. Vascular Access for Dialytic Therapies, 1050
    3. Diagnostic and Interventional Nephrology, 1062
    4. Hemodialysis: Principles and Techniques, 1073
    5. Hemodialysis: Dialysis Prescription and Adequacy, 1082
    6. Acute Complications During Hemodialysis, 1090
    7. Peritoneal Dialysis: Principles, Techniques, and Adequacy, 1103
    8. Complications of Peritoneal Dialysis, 1114
    9. Extracorporeal Therapies for Drug Overdose and Poisoning, 1124
    10. Plasma Exchange, 1132
19. SECTION XIX Transplantation
    1. Immunologic Principles in Kidney Transplantation, 1141
    2. Immunosuppressive Medications in Kidney Transplantation, 1154
    3. Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor, 1163
    4. Kidney Transplantation Surgery, 1174
    5. Prophylaxis and Treatment of Kidney Transplant Rejection, 1186
    6. Medical Management of the Kidney Transplant Recipient: Infections and Malignancies, 1198
    7. Medical Management of the Kidney Transplant Recipient: Cardiovascular Disease and Metabolic
    8. Abnormalities, 1213
    9. Chronic Allograft Injury, 1226
    10. Recurrent Disease in Kidney Transplantation, 1236
    11. Outcomes of Renal Transplantation, 1247
    12. Pancreas and Islet Transplantation, 1258
    13. Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Stem Cell Transplantation, 1272
20. SECTION XX Palliative Nephrology
    1. Palliative Nephrology, 1282
    2. Index, 1289

Authors Biography

Richard J. Johnson, MD, Professor of Medicine, Division Chief, Tomas Berl Professor of Nephrology, University of Colorado–Denver, Denver, Colorado, USA ;

John Feehally, DM, FRCP, Professor of Renal Medicine, The John Walls Renal Unit, Leicester General Hospital, Leicester, United Kingdom;

Jurgen Floege, MD, FERA, Professor of Medicine, Director, Division of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany and

Marcello Tonelli, MD, SM, FRCPC, Associate Vice President of Health Research, University of Calgary, Senior Associate Dean of Clinical Research, Cumming School of Medicine, Professor of Medicine, University of Calgary, Calgary, Alberta, Canada