Diagnostic Pathology: Blood and Bone Marrow (2nd Edition)

Description

Part of the highly regarded Diagnostic Pathology series, Diagnostic Pathology: Blood and Bone Marrow, second edition includes today’s most recent knowledge on the latest finds in this subspecialty. New chapters focus on current molecular insights into the pathogenesis of familial disorders and neoplasms, ensuring pathologists, hematopathologists, hematologists, and oncologists alike can deliver the most up-to-date diagnoses possible. Concise, bulleted text coupled with extensive illustrations makes this succinct yet comprehensive reference ideal for clinical use.

Key Features

• Expert Consult eBook version included, which allows you to search all of the text, figures, and references from the book on a variety of devices
• Includes an introductory chapter on the basics of hematopathology, such as a review of normal peripheral blood and bone marrow histology, flow charts of hematopoiesis, photomicrographs of the various stages of each lineage, and descriptions of the common stains used in hematopathology
• Multiple new chapters focus on current molecular insights into the pathogenesis of familial disorders and neoplasms
• Features a new chapter on familial leukemia propensity disorder
• Content covers many of today’s hot topics, incorporating the recently published WHO criteria in the Revised 4th Edition WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues (IARC, Lyon, 2017), novel genetic subtypes of acute lymphoblastic leukemia, multiple new lymphoma subtypes, clinical practice guidelines for diagnosis of acute leukemias, and hematologic problems of the elderly
• Pinpoints important elements in the diagnosis of benign and neoplastic disorders
• Clearly delineates numerous genetic disorders often found in blood and bone marrow
• Ideal for trainees seeking basic information as well as experienced practitioners in need of a brief refresher

Table of Contents

1.  Part I: Introduction
   1. Hematopoiesis and Bone Marrow Histology
   2. Bone Marrow Examination and Techniques
   3. Bone Marrow Reporting
   4. Overview of Constitutional and Acquired Bone Marrow Disorders
2. Part II: Anemia
   1. Overview of Anemia
   2. SECTION 1: ACQUIRED ANEMIAS
      1. Iron Deficiency Anemia
      2. Autoimmune Hemolytic Anemias
      3. Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn
      4. Microangiopathic Hemolytic Anemia
      5. Megaloblastic Anemia
      6. Acquired Nonneoplastic Sideroblastic Anemia
      7. Alcoholism-Associated Anemia
      8. Anemia in the Elderly
      9. Copper Deficiency-Associated Anemia
      10. Acquired Red Cell Aplasia
      11. Transient Erythroblastopenia of Childhood
      12. Parvovirus-Induced Red Cell Aplasia
      13. Paroxysmal Nocturnal Hemoglobinuria
      14. Acquired Aplastic Anemia
   3. SECTION 2: CONSTITUTIONAL ANEMIAS
      1. Thalassemia
      2. Sickle Cell Anemia
      3. Pyruvate Kinase Deficiency
      4. Hereditary Spherocytosis
      5. Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis
      6. Diamond-Blackfan Anemia
      7. Fanconi Anemia
      8. Congenital Dyserythropoietic Anemia
      9. Congenital Sideroblastic Anemia
      10. Congenital Megaloblastic Anemia
3. Part III: Erythrocytosis
   1. SECTION 1: CONSTITUTIONAL
      1. Congenital Erythrocytosis
   2. SECTION 2: ACQUIRED
      1. Acquired Erythrocytosis
4. Part IV: Benign Leukocyte Disorders in Blood and Bone Marrow
   1. Overview of Benign Leukocyte Disorders in Blood and Bone Marrow
   2. Pancytopenia
   3. Neutropenia
   4. Neutrophilia
   5. Monocytosis
   6. Eosinophilia
   7. Basophilia
   8. Lymphocytosis
   9. Lymphopenia, Constitutional and Acquired
   10. Plasmacytosis of Bone Marrow
   11. Hematogones in Bone Marrow
   12. Lymphoid Aggregates in Bone Marrow
   13. Granulomas in Bone Marrow
5. Part V: Constitutional Granulocytic Disorders
   1. SECTION 1: CONSTITUTIONAL NEUTROPENIAS
      1. Severe Congenital Neutropenia and Cyclic Neutropenia
      2. Shwachman-Diamond Syndrome
      3. Chediak-Higashi Syndrome
      4. Myelokathexis in WHIM Syndrome
   2. SECTION 2: CONSTITUTIONAL NEUTROPHIL ANOMALIES
      1. Pelger-Huet Anomaly
      2. MYH9-Related Disorders
      3. Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation
6. Part VI: Megakaryocytic Disorders
   1. Overview of Megakaryocytic Disorders
   2. SECTION 1: ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA
      1. Immune-Mediated Thrombocytopenia
      2. Hemolytic-Uremic Syndrome
      3. Thrombotic Thrombocytopenic Purpura
      4. Pregnancy-Associated Thrombocytopenia
   3. SECTION 2: CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA
      1. Thrombocytopenia Absent Radius Syndrome
      2. Congenital Amegakaryocytic Thrombocytopenia
      3. Gray Platelet Syndrome
      4. Wiskott-Aldrich Syndrome-Related Disorders
      5. Congenital Thrombotic Thrombocytopenic Purpura
   4. SECTION 3: THROMBOCYTOSIS
      1. Thrombocytosis
7. Part VII: Infection
   1. Overview of Infection
   2. Hantavirus Pulmonary Syndrome
   3. Human Immunodeficiency Virus
   4. Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)
   5. Parvovirus B19 Infection
   6. Bacterial Infections, Blood and Bone Marrow Features
   7. Fungal Infections, Blood and Bone Marrow Features
   8. Helminthic Infections
   9. Malaria
   10. Other Protozoan Infections
8. Part VIII: Miscellaneous Nonneoplastic Disorders and Conditions
   1. Overview and Classification of Hemophagocytic Disorders in Bone Marrow
   2. Hematologic Manifestations of Collagen Vascular Disorders
   3. Hematologic Manifestations of Chronic Renal Disorders
   4. Lysosomal Storage Diseases With Predominantly Histiocytic Storage
   5. Other Pregnancy-Associated Hematologic Disorders
   6. Gelatinous Transformation and Other Bone Marrow Stromal Disorders
   7. Crystals in Bone Marrow
   8. Bone Abnormalities in Bone Marrow Specimens
9. Part IX: Myeloid Neoplasms
   1. Overview and Classification of Myeloid Neoplasms
   2. Protocol for the Examination of Specimens From Patients With Hematopoietic Neoplasms Involving Bone Marrow
   3. Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia
   4. SECTION 1: MYELOPROLIFERATIVE NEOPLASMS
      1. Overview of Myeloproliferative Neoplasms
      2. Chronic Myelogenous Leukemia, BCR/ABL1+
      3. Chronic Neutrophilic Leukemia
      4. Polycythemia Vera
      5. Primary Myelofibrosis
      6. Essential Thrombocythemia
      7. Chronic Eosinophilic Leukemia, Not Otherwise Specified
      8. Systemic Mastocytosis
      9. Mast Cell Leukemia
      10. Myeloproliferative Neoplasm, Unclassifiable
   5. SECTION 2: MYELOID AND LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND ABNORMALITIES OF PDGFRA, PDGFRB, AND FGFR1
      1. Myeloid and Lymphoid Neoplasms With PDGFRA Rearrangement
      2. Myeloid Neoplasms With PDGRFB Rearrangments
      3. Myeloid and Lymphoid Neoplasms With FGFR1 Abnormalities
   6. SECTION 3: MYELODYSPLASTIC & MYELOPROLIFERATIVE NEOPLASMS
      1. Overview of Myelodysplastic/Myeloproliferative Neoplasms
      2. Chronic Myelomonocytic Leukemia
      3. Atypical Chronic Myeloid Leukemia, BCR/ABL1-
      4. Juvenile Myelomonocytic Leukemia
      5. RARS-T
      6. Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable
   7. SECTION 4: MYELODYSPLASTIC SYNDROMES
      1. Overview and Classification of Myelodysplastic Syndromes
      2. Myelodysplasia With Single Lineage Dysplasia
      3. Myelodysplasia With Ring Sideroblasts
      4. Myelodysplasia With Multilineage Dysplasia
      5. Myelodysplasia With Increased Blasts
      6. Myelodysplastic Syndrome With Isolated del(5q)
      7. Myelodysplastic Syndrome, Unclassifiable
      8. Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)
   8. SECTION 5: ACUTE MYELOID LEUKEMIA
      1. Overview of Acute Myeloid Leukemia
      2. Familial AML/MDS
      3. Acute Myeloid Leukemia With t(8;21)(q22;q22), RUNX1-RUNX1T1
      4. Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), CBFB-MYH11
      5. Acute Promyelocytic Leukemia With t(15;17)(q22;q21), PML-RARA
      6. Acute Promyelocytic Leukemia With Variant RARA Rearrangement
      7. Acute Myeloid Leukemia With t(9;11)(p22;q23), MLLT3-MLL
      8. Additional Genetic Subtypes of Acute Myeloid Leukemia, Including t(6;9), inv(3), t(1;22), Mutated NPM1, Mutated CEBPA
      9. Acute Myeloid Leukemia With Myelodysplasia- Related Changes
      10. Therapy-Related Myeloid Neoplasms
      11. Acute Myeloid Leukemia With Minimal Differentiation
      12. Acute Myeloid Leukemia Without Maturation
      13. Acute Myeloid Leukemia With Maturation
      14. Acute Myelomonocytic Leukemia
      15. Acute Monoblastic and Monocytic Leukemia
      16. Acute Erythroid Leukemia
      17. Acute Megakaryoblastic Leukemia
      18. Acute Basophilic Leukemia
      19. Acute Panmyelosis With Myelofibrosis
      20. Myeloid Proliferations Related to Down Syndrome
      21. Blastic Plasmacytoid Dendritic Cell Neoplasm
10. Part X: Acute Leukemias of Ambiguous Lineage
    1. Acute Undifferentiated Leukemia
    2. Mixed Phenotype Acute Leukemia
11. Part XI: Lymphoid Neoplasms
    1. Overview of Lymphoid Neoplasms
    2. Protocol for the Examination of Specimens from Patients With Non-Hodgkin Lymphoma/Lymphoid Neoplasms
    3. SECTION 1: B-PRECURSOR NEOPLASMS
       1. B-Lymphoblastic Leukemia
       2. Novel Genetic Subtypes of B-Lymphoblastic Leukemia
    4. SECTION 2: T-PRECURSOR NEOPLASMS
       1. T-Lymphoblastic Leukemia/Lymphoma
       2. ETP-ALL
    5. SECTION 3: MATURE B-CELL NEOPLASMS
       1. Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas
       2. Monoclonal B Lymphocytes
       3. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
       4. B-Cell Prolymphocytic Leukemia
       5. Splenic B-Cell Marginal Zone Lymphoma
       6. Hairy Cell Leukemia
       7. Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant
       8. Lymphoplasmacytic Lymphoma
       9. Gamma Heavy Chain Disease
       10. Monoclonal Gammopathy of Undetermined Significance
       11. Plasma Cell Myeloma
       12. Burkitt Leukemia/Lymphoma
       13. Mantle Cell Lymphoma in Blood and Bone Marrow
       14. Follicular Cell Lymphoma in Blood and Bone Marrow
       15. Marginal Zone Lymphoma in Blood and Bone Marrow
       16. Large Cell Lymphoma in Blood and Bone Marrow
       17. Other B-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow
    6. SECTION 4: MATURE T/NK-CELL NEOPLASMS
       1. Overview and Classification of Mature T/NK-Cell Neoplasms
       2. T-Cell Prolymphocytic Leukemia
       3. T-Cell Large Granular Lymphocytic Leukemia
       4. Chronic Lymphoproliferative Disorder of NK Cells
       5. Aggressive NK-Cell Leukemia
       6. Adult T-Cell Leukemia
       7. Mycosis Fungoides/Sézary Syndrome
       8. Anaplastic Large Cell Lymphoma in Blood and Bone Marrow
       9. Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow
    7. SECTION 5: HODGKIN LYMPHOMA IN BONE MARROW
       1. Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes
       2. Protocol for the Examination of Specimens from Patients With Hodgkin Lymphoma
12. Part XII: Other Neoplasms Involving Bone Marrow
    1. Langerhans Cell Histiocytosis in Bone Marrow
    2. Hemophagocytic Disorders
    3. Posttransplant Lymphoproliferative Disorders in Bone Marrow
    4. Metastatic Carcinoma and Sarcoma

Authors Biography

Kathryn Foucar, MD, Distinguished Professor Emerita of Pathology Department of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico ;

Devon Chabot-Richards, MD, Assistant Professor, The University of New Mexico, Albuquerque, New Mexico;

David Czuchlewski, MD, Associate Professor, Vice Chair for Education, Department of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico;

Kristin Hunt Karner, MD, Assistant Professor, Department of Pathology, University of Utah, Medical Director, Hematopathology, ARUP Laboratories, Salt Lake City, Utah;

Kaaren K. Reichard, MD, Consultant, Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic, Rochester, Minnesota;

Mohammad A Vasef, MD, Professor of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico;

Carla S. Wilson, MD, PhD, Professor of Pathology, Department of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico;

Qian-Yun Zhang, MD, PhD, Professor of Pathology, Department of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico and

Karissa Culbreath, PhD, D(ABMM), Assistant Professor, Department of Pathology, The University of New Mexico Health Sciences Center, Scientific Director, Infectious Disease, TriCore Reference Laboratories, Albuquerque, New Mexico