Goodman and Gilman’s The Pharmacological Basis of Therapeutics (13th Edition)

Description

The most universally respected and read text in all of pharmacology – updated with the latest breakthroughs and developments

Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease.

Enriched by a full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the thirteenth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents.

• NEW chapters on hypertension therapy, myocardial ischemia therapy, treatment of pulmonary arterial hypertension, immunostimulants and vaccines, and treatment of viral hepatitis, as well as appendices on prescription order writing, patient compliance, and pharmacokinetics
• 440+ full-color illustrations
• More than a textbook, a working template for the effective and rational prescribing of drugs in daily practice

Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13e is divided into nine sections, covering:

• General Principles
• Neuropharmacology
• Modulation of Pulmonary, Renal, and Cardiovascular Function
• Inflammation, Immunomodulation, and Hematopoiesis
• Endocrine Pharmacology
• Gastrointestinal Pharmacology
• Chemotherapy of Infectious Disease
• Chemotherapy of Neoplastic Diseases
• Special Systems Pharmacology

Table of Contents

1. Preface
2. Acknowledgments
3. Section I General Principles 1
   1. Drug Invention and the Pharmaceutical Industry
   2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination
   3. Pharmacodynamics: Molecular Mechanisms of Drug Action
   4. Drug Toxicity and Poisoning
   5. Membrane Transporters and Drug Response
   6. Drug Metabolism
   7. Pharmacogenetics
4. Section II Neuropharmacology
   1. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems
   2. Muscarinic Receptor Agonists and Antagonists
   3. Anticholinesterase Agents
   4. Nicotine and Agents Acting at the Neuromuscular Junction and Autonomic Ganglia
   5. Adrenergic Agonists and Antagonists
   6. 5-Hydroxytryptamine (Serotonin) and Dopamine
   7. Neurotransmission in the Central Nervous System
   8. Drug Therapy of Depression and Anxiety Disorders
   9. Pharmacotherapy of Psychosis and Mania
   10. Pharmacotherapy of the Epilepsies
   11. Treatment of Central Nervous System Degenerative Disorders
   12. Hypnotics and Sedatives
   13. Opioids, Analgesia, and Pain Management
   14. General Anesthetics and Therapeutic Gases
   15. Local Anesthetics
   16. Ethanol
   17. Drug Use Disorders and Addiction
5. Section III Modulation of Pulmonary, Renal, and Cardiovascular Function
   1. Drugs Affecting Renal Excretory Function
   2. Renin and Angiotensin
   3. Treatment of Ischemic Heart Disease
   4. Treatment of Hypertension
   5. Therapy of Heart Failure
   6. Antiarrhythmic Drugs
   7. Treatment of Pulmonary Arterial Hypertension
   8. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs
   9. Drug Therapy for Dyslipidemias
6. Section IV Inflammation, Immunomodulation, and Hematopoiesis
   1. Introduction to Immunity and Inflammation
   2. Immunosuppressants and Tolerogens
   3. Immune Globulins and Vaccines
   4. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor
   5. Pharmacotherapy of Inflammation, Fever, Pain, and Gout
   6. Histamine, Bradykinin, and Their Antagonists
   7. Pulmonary Pharmacology
   8. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins
7. Section V Hormones and Hormone Antagonists
   1. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis
   2. Thyroid and Antithyroid Drugs
   3. Estrogens, Progestins, and the Female Reproductive Tract
   4. Androgens and the Male Reproductive Tract
   5. Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex
   6. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia
   7. Agents Affecting Mineral Ion Homeostasis and Bone Turnover
8. Section VI Gastrointestinal Pharmacology
   1. Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease
   2. Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease
   3. Pharmacotherapy of Inflammatory Bowel Disease
9. Section VII Chemotherapy of Infectious Diseases
   1. General Principles of Antimicrobial Therapy
   2. Chemotherapy of Malaria
   3. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections
   4. Chemotherapy of Helminth Infections
   5. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections
   6. Penicillins, Cephalosporins, and Other ?-Lactam Antibiotics
   7. Aminoglycosides
   8. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents
   9. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy
   10. Antifungal Agents
   11. Antiviral Agents (Nonretroviral)
   12. Treatment of Viral Hepatitis (HBV/HCV)
   13. Antiretroviral Agents and Treatment of HIV Infection
   14. Section VIII Pharmacotherapy of Neoplastic Disease
   15. General Principles in the Pharmacotherapy of Cancer
   16. Cytotoxic Drugs
   17. Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules
   18. Hormones and Related Agents in the Therapy of Cancer
10. Section IX Special Systems Pharmacology
    1. Ocular Pharmacology
    2. Dermatological Pharmacology
    3. Environmental Toxicology: Carcinogens and Heavy Metals
    4. Appendices
    5. I. Principles of Prescription Order Writing and Patient Compliance
    6. II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data
    7. Index

Author Biography

Laurence L. Brunton, PhD
Professor of Pharmacology and Medicine
University of California, San DiegoLaurence Brunton trained under Alfred Goodman-Gilman and is nationally recognized for his expertise in cell signaling and cardivacular pharmacology. He has published more than 200 original research papers.