Harrison’s Principles of Internal Medicine (20th Edition) (Vol. 1 & Vol. 2) | KitaabNow

Harrison’s Principles of Internal Medicine (20th Edition) (Vol. 1 & Vol. 2)

  • Authors: J. Larry Jameson, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, Dan L. Longo, Joseph Loscalzo
  • ISBN: 9781259644030
  • Publisher: McGraw Hill Education
  • Edition: 20th
  • Publication Date: July 23, 2018
  • Format: Hardback – 4048 pages
  • Language: English

A Doody’s Core Title for 2021!

Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine

The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms

Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.

Essential for practice and education, the landmark 20th Edition features:

  • Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.
  • State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.
  • All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.
  • Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice.
  • Updated clinical guidelines, expert opinions, and treatment approaches from renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient
Table of Contents
  3. Part 1: The Profession of Medicine
    1. The Practice of Medicine – The Editors
    2. Promoting Good Health – Donald M. Lloyd-Jones, Kathleen M. McKibbin
    3. Decision-Making in Clinical Medicine – Daniel B. Mark, John B. Wong
    4. Screening and Prevention of Disease – Katrina A. Armstrong, Gary J. Martin
    5. Health Care Systems in Developed Countries – Richard B. Saltman
    6. The Safety and Quality of Health Care – David W. Bates
    7. Racial and Ethnic Disparities in Health Care – Joseph R. Betancourt, Alexander R. Green
    8. Ethical Issues in Clinical Medicine – Bernard Lo, Christine Grady
    9. Palliative and End-of-Life Care – Ezekiel J. Emanuel
  4. Part 2: Cardinal Manifestations and Presentation of Diseases –
    1. Section 1: Pain 
      1. Pain: Pathophysiology and Management – James P. Rathmell, Howard L. Fields
      2. Chest Discomfort – David A. Morrow
      3. Abdominal Pain – Danny O. Jacobs
      4. Headache – Peter J. Goadsby
      5. Back and Neck Pain – John W. Engstrom
    2. Section 2: Alterations in Body Temperature
      1. Fever – Charles A. Dinarello, Reuven Porat
      2. Fever and Rash – Elaine T. Kaye, Kenneth M. Kaye
      3. Fever of Unknown Origin – Chantal P. Bleeker-Rovers, Jos W. M. van der Meer
    3.  Section 3: Nervous System Dysfunction
      1. Syncope – Roy Freeman
      2. Dizziness and Vertigo – Mark F. Walker, Robert B. Daroff
      3. Fatigue – Jeffrey M. Gelfand, Vanja C. Douglas
      4. Neurologic Causes of Weakness and Paralysis – Michael J. Aminoff
      5. Numbness, Tingling, and Sensory Loss – Michael J. Aminoff
      6. Gait Disorders, Imbalance and Falls – Jessica M. Baker, Lewis R. Sudarsky
      7. Confusion and Delirium – S. Andrew Josephson, Bruce L. Miller
      8. Dementia – William W. Seeley, Bruce L. Miller
      9. Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral Disorders – M.-Marsel Mesulam
      10. Sleep Disorders – Thomas E. Scammell, Clifford B. Saper, Charles A. Czeisler
    4. Section 4: Disorders of Eyes, Ears, Nose, and Throat
      1. Disorders of the Eye – Jonathan C. Horton
      2. Disorders of Smell and Taste – Richard L. Doty, Steven M. Bromley
      3. Disorders of Hearing – Anil K. Lalwani
      4. Sore Throat, Earache, and Upper Respiratory Symptoms – Michael A. Rubin, Larry C. Ford, Ralph Gonzales
      5. Oral Manifestations of Disease – Samuel C. Durso 
    5. Section 5: Alterations in Circulatory and Respiratory Functions
      1. Dyspnea – Rebecca M. Baron
      2. Cough  – Christopher H. Fanta
      3. Hemoptysis – Anna K. Brady, Patricia A. Kritek
      4. Hypoxia and Cyanosis – Joseph Loscalzo
      5. Edema – Eugene Braunwald, Joseph Loscalzo
      6. Approach to the Patient with a Heart Murmur – Patrick T. O’Gara, Joseph Loscalzo
      7. Palpitations – Joseph Loscalzo
    6. Section 6: Alterations in Gastrointestinal Function
      1. Dysphagia – Ikuo Hirano, Peter J. Kahrilas
      2. Nausea, Vomiting, and Indigestion – William L. Hasler
      3. Diarrhea and Constipation – Michael Camilleri, Joseph A. Murray
      4. Unintentional Weight Loss – J. Larry Jameson
      5. Gastrointestinal Bleeding – Loren Laine
      6. Jaundice – Savio John, Daniel S. Pratt
      7. Abdominal Swelling and Ascites – Kathleen E. Corey, Lawrence S. Friedman
    7. Section 7: Alterations in Renal and Urinary Tract Function
      1. Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain Syndrome – John W. Warren
      2. Azotemia and Urinary Abnormalities – David B. Mount
      3. Fluid and Electrolyte Disturbances – David B. Mount
      4. Hypercalcemia and Hypocalcemia – Sundeep Khosla
      5. Acidosis and Alkalosis – Thomas D. DuBose, Jr.
    8. Section 8: Alterations in the Skin
      1. Approach to the Patient with a Skin Disorder – Kim B. Yancey, Thomas J. Lawley
      2. Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders – Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley
      3. Skin Manifestations of Internal Disease – Jean L. Bolognia, Irwin M. Braverman
      4. Immunologically Mediated Skin Diseases – Kim B. Yancey, Thomas J. Lawley
      5. Cutaneous Drug Reactions – Robert G. Micheletti, Misha Rosenbach, Bruce U. Wintroub, Kanade Shinkai
      6. Photosensitivity and Other Reactions to Light – Alexander G. Marneros, David R. Bickers
    9. Section 9: Hematologic Alterations
      1. Interpreting Peripheral Blood Smears  – Dan L. Longo
      2. Anemia and Polycythemia – John W. Adamson, Dan L. Longo
      3. Disorders of Granulocytes and Monocytes – Steven M. Holland, John I. Gallin
      4. Bleeding and Thrombosis – Barbara A. Konkle
      5. Enlargement of Lymph Nodes and Spleen – Dan L. Longo
  5. Part 3: Pharmacology
    1. Principles of Clinical Pharmacology – Dan M. Roden
    2. Pharmacogenomics – Dan M. Roden
  6. Part 4: Oncology and Hematology
    1. Section 1: Neoplastic Disorders
      1. Approach to the Patient with Cancer – Dan L. Longo
      2. Prevention and Early Detection of ?Cancer – Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer
      3. Cancer Genetics – Fred Bunz, Bert Vogelstein
      4. Cancer Cell Biology – Jeffrey W. Clark, Dan L. Longo
      5. Principles of Cancer Treatment – Edward A. Sausville, Dan L. Longo
      6. Infections in Patients with Cancer – Robert W. Finberg
      7. Oncologic Emergencies – Rasim Gucalp, Janice P. Dutcher
      8. Cancer of the Skin – Brendan D. Curti, Sancy Leachman, Walter J. Urba 
      9. Head and Neck Cancer – Everett E. Vokes
      10. Neoplasms of the Lung – Leora Horn, Christine M. Lovly
      11. Breast Cancer – Daniel F. Hayes, Marc E. Lippman
      12. Upper Gastrointestinal Tract Cancers – Robert J. Mayer
      13. Lower Gastrointestinal Cancers – Robert J. Mayer
      14. Tumors of the Liver and Biliary Tree – Josep M. Llovet
      15. Pancreatic Cancer – Daniel D. Von Hoff
      16. Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas – Robert T. Jensen
      17. Renal Cell Carcinoma – Robert J. Motzer
      18. Cancer of the Bladder and Urinary Tract – Noah M. Hahn
      19. Benign and Malignant Diseases of the Prostate – Howard I. Scher, James A. Eastham
      20. Testicular Cancer – David J. Vaughn
      21. Gynecologic Malignancies – David Spriggs
      22. Primary and Metastatic Tumors of the Nervous System – Lisa M. DeAngelis, Patrick Y. Wen
      23. Soft Tissue and Bone Sarcomas and Bone Metastases – Shreyaskumar R. Patel
      24. Carcinoma of Unknown Primary – Gauri R. Varadhachary, James L. Abbruzzese
      25. Paraneoplastic Syndromes: Endocrinologic/Hematologic – J. Larry Jameson, Dan L. Longo
      26. Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis – Josep Dalmau, Myrna R. Rosenfeld
      27. Late Consequences of Cancer and Its Treatment – Carl E. Freter, Dan L. Longo
    2. Section 2: Hematopoietic Disorders
      1. Hematopoietic Stem Cells – David T. Scadden, Dan L. Longo
      2. Iron Deficiency and Other Hypoproliferative Anemias – John W. Adamson
      3. Disorders of Hemoglobin – Edward J. Benz, Jr.
      4. Megaloblastic Anemias – A. Victor Hoffbrand
      5. Hemolytic Anemias  – Lucio Luzzatto
      6. Anemia Due to Acute Blood Loss – Dan L. Longo
      7. Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia – Neal S. Young
      8. Polycythemia Vera and Other Myeloproliferative Neoplasms – Jerry L. Spivak
      9. Acute Myeloid Leukemia – William Blum, Clara D. Bloomfield
      10. Chronic Myeloid Leukemia – Hagop Kantarjian, Jorge Cortes
      11. Acute Lymphoid Leukemia – Dieter Hoelzer 
      12. Chronic Lymphocytic Leukemia – Jennifer A. Woyach, John C. Byrd
      13. Non-Hodgkin’s Lymphoma – Caron A. Jacobson, Dan L. Longo
      14. Hodgkin’s Lymphoma  – Caron A. Jacobson, Dan L. Longo
      15. Less Common Hematologic Malignancies – Ayalew Tefferi, Dan L. Longo
      16. Plasma Cell Disorders – Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson
      17. Amyloidosis – John L. Berk, Vaishali Sanchorawala 
      18. 109 Transfusion Biology and Therapy – Jeffery S. Dzieczkowski, Pierre Tiberghien, Kenneth C. Anderson
      19. Hematopoietic Cell Transplantation – Frederick R. Appelbaum
    3. Section 3: Disorders of Hemostasis
      1. Disorders of Platelets and Vessel Wall – Barbara A. Konkle
      2. Coagulation Disorders – Valder R. Arruda, Katherine A. High
      3. Arterial and Venous Thrombosis – Jane E. Freedman, Joseph Loscalzo
      4. Antiplatelet, Anticoagulant, and Fibrinolytic Drugs – Jeffrey I. Weitz
  7. Part 5: Infectious Diseases
    1. Section 1: Basic Considerations in Infectious Diseases
      1. Approach to the Patient with an Infectious Disease – Neeraj K. Surana, Dennis L. Kasper
      2. Molecular Mechanisms of Microbial Pathogenesis – Gerald B. Pier
      3. Approach to the Acutely Ill Infected Febrile Patient – Tamar F. Barlam, Dennis L. Kasper
      4. Immunization Principles and Vaccine Use – Nancy Messonnier, Anne Schuchat, Lisa A. Jackson
      5. Health Recommendations for International Travel – Jay S. Keystone, Phyllis E. Kozarsky
      6. Climate Change and Infectious Disease – Aaron S. Bernstein
    2. Section 2: Clinical Syndromes: Community-Acquired Infections
      1. Pneumonia – Lionel A. Mandell, Richard G. Wunderink
      2. Lung Abscess – Rebecca M. Baron, Miriam Baron Barshak
      3. Infective Endocarditis – Adolf W. Karchmer
      4. Infections of the Skin, Muscles, and Soft Tissues – Dennis L. Stevens
      5. Infectious Arthritis – Lawrence C. Madoff
      6. Osteomyelitis – Werner Zimmerli
      7. Intraabdominal Infections and Abscesses – Miriam Baron Barshak, Dennis L. Kasper
      8. Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning – Richelle C. Charles, Stephen B. Calderwood, Regina C. LaRocque
      9. Clostridium difficile Infection, Including Pseudomembranous Colitis – Dale N. Gerding, Stuart Johnson
      10. Urinary Tract Infections, Pyelonephritis, and Prostatitis – Kalpana Gupta, Barbara W. Trautner
      11. Sexually Transmitted Infections: Overview and Clinical Approach – Jeanne M. Marrazzo, King K. Holmes
      12. Encephalitis – Karen L. Roos, Kenneth L. Tyler
      13. Acute Meningitis – Karen L. Roos, Kenneth L. Tyler
      14. Chronic and Recurrent Meningitis – Walter J. Koroshetz, Michael R. Wilson, Avindra Nath
      15. Brain Abscess and Empyema – Karen L. Roos, Kenneth L. Tyler
      16. Infectious Complications of Bites – Sandeep S. Jubbal, Florencia Pereyra, Lawrence C. Madoff
    3. Section 3: Clinical Syndromes: Health Care-Associated Infections
      1. Infections Acquired in Health Care Facilities – Robert A. Weinstein
      2. Infections in Transplant Recipients – Robert W. Finberg, Joyce D. Fingeroth
    4. Section 4: Therapy for Bacterial Diseases
      1. Treatment and Prophylaxis of Bacterial Infections – David C. Hooper, Erica S. Shenoy, Christy A. Varughese
      2. Bacterial Resistance to Antimicrobial Agents – David C. Hooper
    5. Section 5: Diseases Caused by Gram-Positive Bacteria
      1. Pneumococcal Infections – David Goldblatt, Katherine L. O’Brien
      2. Staphylococcal Infections – Franklin D. Lowy
      3. Streptococcal Infections – Michael R. Wessels
      4. Enterococcal Infections – Cesar A. Arias, Barbara E. Murray
      5. Diphtheria and Other Corynebacterial Infections – William R. Bishai, John R. Murphy
      6. Listeria monocytogenes Infections – Elizabeth L. Hohmann, Daniel A. Portnoy
      7. Tetanus – C. Louise Thwaites, Lam Minh Yen
      8. Botulism – Agam K. Rao, Susan Maslanka
      9. Gas Gangrene and Other Clostridial Infections – Amy E. Bryant, Dennis L. Stevens
    6. Section 6: Diseases Caused by Gram-Negative Bacteria
      1. Meningococcal Infections – Andrew J. Pollard 
      2. Gonococcal Infections – Sanjay Ram, Peter A. Rice
      3. Haemophilus and Moraxella Infections – Timothy F. Murphy
      4. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria – Tamar F. Barlam, Dennis L. Kasper
      5. Legionella Infections – Victor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin
      6. Pertussis and Other Bordetella Infections – Karina A. Top, Scott A. Halperin
      7. Diseases Caused by Gram-Negative Enteric Bacilli – Thomas A. Russo, James R. Johnson
      8. Acinetobacter Infections – Rossana Rosa, L. Silvia Munoz-Price
      9. Helicobacter pylori Infections – John C. Atherton, Martin J. Blaser
      10. Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species – Reuben Ramphal
      11. Salmonellosis – David A. Pegues, Samuel I. Miller
      12. Shigellosis – Philippe J. Sansonetti, Jean Bergounioux
      13. Infections Due to Campylobacter and Related Organisms – Beth D. Kirkpatrick, Martin J. Blaser
      14. Cholera and Other Vibrioses – Matthew K. Waldor, Edward T. Ryan 
      15. Brucellosis – Nicholas J. Beeching
      16. Tularemia – Jeannine M. Petersen, Paul S. Mead
      17. Plague and Other Yersinia Infections – Michael B. Prentice
      18. Bartonella Infections, Including Cat-Scratch Disease – Michael Giladi, Moshe Ephros
      19. Donovanosis – Nigel O’Farrell
    7. Section 7: Miscellaneous Bacterial Infections
      1. Nocardiosis – Gregory A. Filice
      2. Actinomycosis  – Thomas A. Russo
      3. Whipple’s Disease – Thomas A. Russo
      4. Infections Due to Mixed Anaerobic Organisms – Neeraj K. Surana, Dennis L. Kasper
    8. Section 8: Mycobacterial Diseases
      1. Tuberculosis – Mario C. Raviglione
      2. Leprosy – Robert H. Gelber
      3. Nontuberculous Mycobacterial Infections – Steven M. Holland
      4. Antimycobacterial Agents – Divya Reddy, Max R. O’Donnell
    9. Section 9: Spirochetal Diseases
      1. Syphilis – Sheila A. Lukehart
      2. Endemic Treponematoses – Sheila A. Lukehart
      3. Leptospirosis  – Jii F. P. Wagenaar, Marga G. A. Goris
      4. Relapsing Fever – Alan G. Barbour
      5. Lyme Borreliosis – Allen C. Steere
    10.  Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
      1. Rickettsial Diseases – David H. Walker, J. Stephen Dumler, Lucas S. Blanton, Thomas J. Marrie
      2. Infections Due to Mycoplasmas – R. Doug Hardy
      3. Chlamydial Infections – Charlotte A. Gaydos, Thomas C. Quinn
    11. Section 11: Viral Diseases: General Considerations
      1. Medical Virology – Fred Wang, Elliott Kieff
      2. Antiviral Chemotherapy, Excluding Antiretroviral Drugs – Lindsey R. Baden
    12.  Section 12: Infections Due to DNA Viruses
      1. Herpes Simplex Virus Infections – Lawrence Corey
      2. Varicella-Zoster Virus Infections – Richard J. Whitley
      3. Epstein-Barr Virus Infections, Including Infectious Mononucleosis – Jeffrey I. Cohen
      4. Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 – Camille Nelson Kotton, Martin S. Hirsch
      5. Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections – Fred Wang
      6. Parvovirus Infections – Kevin E. Brown
      7. Human Papillomavirus Infections – Darron R. Brown, Aaron Ermel
    13. Section 13: Infections Due to DNA and RNA Respiratory Viruses
      1. Common Viral Respiratory Infections  – James E. Crowe, Jr.
      2. Influenza – Peter F. Wright
    14. Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
      1. The Human Retroviruses – Dan L. Longo, Anthony S. Fauci
      2. Human Immunodeficiency Virus Disease: AIDS and Related Disorders – Anthony S. Fauci, Gregory K. Folkers, H. Clifford Lane
    15. Section 15: Infections Due to RNA Viruses
      1. Viral Gastroenteritis – Umesh D. Parashar, Roger I. Glass
      2. Enterovirus, Parechovirus, and Reovirus Infections – Jeffrey I. Cohen
      3. Measles (Rubeola) – Kaitlin Rainwater-Lovett, William J. Moss
      4. Rubella (German Measles) – Laura A. Zimmerman, Susan E. Reef
      5. Mumps – Steven A. Rubin
      6. Rabies and Other Rhabdovirus Infections – Alan C. Jackson
      7. Arthropod-Borne and Rodent-Borne Virus Infections – Jens H. Kuhn, Rémi N. Charrel
      8. Ebolavirus and Marburgvirus Infections – Jens H. Kuhn
    16. Section 16: Fungal Infections
      1. Diagnosis and Treatment of Fungal Infections – John E. Edwards, Jr. 
      2. Histoplasmosis – Chadi A. Hage, L. Joseph Wheat
      3. Coccidioidomycosis – Neil M. Ampel
      4. Blastomycosis – S. Travis King, Rathel L. Nolan, III 
      5. Cryptococcosis – Arturo Casadevall
      6. Candidiasis – John E. Edwards, Jr.
      7. Aspergillosis – David W. Denning
      8. Mucormycosis – Brad Spellberg, Ashraf S. Ibrahim
      9. Superficial Mycoses and Less Common Systemic Mycoses – Carol A. Kauffman
      10. Pneumocystis Infections – Alison Morris, Henry Masur
    17. Section 17: Protozoal and Helminthic Infections: General Considerations 
      1. Introduction to Parasitic Infections  – Sharon L. Reed, Charles E. Davis
      2. Agents Used to Treat Parasitic Infections – Thomas A. Moore
    18. Section 18: Protozoal Infections 
      1. Amebiasis and Infection with Free-Living Amebae – Rosa M. Andrade, Sharon L. Reed
      2. Malaria – Nicholas J. White, Elizabeth A. Ashley
      3. Babesiosis – Edouard Vannier, Peter J. Krause
      4. Leishmaniasis – Shyam Sundar
      5. Chagas Disease and African Trypanosomiasis – François Chappuis, Yves Jackson
      6. Toxoplasma Infections – Kami Kim
      7. Protozoal Intestinal Infections and Trichomoniasis – Peter F. Weller
    19. Section 19: Helminthic Infections 
      1. Introduction to Helminthic Infections – Peter F. Weller
      2. Trichinellosis and Other Tissue Nematode Infections – Peter F. Weller
      3. Intestinal Nematode Infections – Peter F. Weller, Thomas B. Nutman
      4. Filarial and Related Infections – Thomas B. Nutman, Peter F. Weller
      5. Schistosomiasis and Other Trematode Infections – Birgitte Jyding Vennervald
      6. Cestode Infections – A. Clinton White, Jr., Peter F. Weller
  8. Part 6: Disorders of the Cardiovascular System
    1. Section 1: Introduction to Cardiovascular Disorders
      1. Approach to the Patient with Possible Cardiovascular Disease – Joseph Loscalzo
      2. Basic Biology of the Cardiovascular System – Joseph Loscalzo, Peter Libby, Calum A. MacRae
      3. Epidemiology of Cardiovascular Disease – Thomas A. Gaziano, J. Michael Gaziano
    2. Section 2: Diagnosis of Cardiovascular Disorders
      1. Physical Examination of the Cardiovascular System – Patrick T. O’Gara, Joseph Loscalzo
      2. Electrocardiography – Ary L. Goldberger
      3. Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed
      4. Tomography Imaging – Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 
      5. Diagnostic Cardiac Catheterization and Coronary Angiography – Jane A. Leopold, David P. Faxon
    3. Section 3: Disorders of Rhythm
      1. Principles of Electrophysiology – David D. Spragg, Gordon F. Tomaselli
      2. The Bradyarrhythmias: Disorders of the Sinoatrial Node – David D. Spragg, Gordon F. Tomaselli
      3. The Bradyarrhythmias: Disorders of the Atrioventricular Node – David D. Spragg, Gordon F. Tomaselli
      4. Approach to Supraventricular Tachyarrhythmias – Gregory F. Michaud, William G. Stevenson
      5. Physiologic and Non-physiologic Sinus Tachycardia  – Gregory F. Michaud, William G. Stevenson
      6. Focal Atrial Tachycardia  – Gregory F. Michaud, William G. Stevenson
      7. Paroxysmal Supraventricular Tachycardias – Gregory F. Michaud, William G. Stevenson
      8. Common Atrial Flutter, Macroreentrant and Multifocal Atrial Tachycardias – Gregory F. Michaud, William G. Stevenson
      9. Atrial Fibrillation – Gregory F. Michaud, William G. Stevenson
      10. Approach to Ventricular Arrhythmias  – Roy M. John, William G. Stevenson
      11. 248 Premature Ventricular Beats, Non-sustained Ventricular Tachycardia, and Idioventricular Rhythm  – Roy M. John, William G. Stevenson
      12. Sustained Ventricular Tachycardia  – William G. Stevenson, Roy M. John
      13. Polymorphic Ventricular Tachycardia and Ventricular Fibrillation – William G. Stevenson, Roy M. John
      14. Electrical Storm and Incessant VT – William G. Stevenson, Roy M. John
    4. Section 4: Disorders of the Heart
      1. Heart Failure: Pathophysiology and Diagnosis – Douglas L. Mann, Murali Chakinala
      2. Heart Failure: Management – Mandeep R. Mehra 
      3. Cardiomyopathy and Myocarditis – Neal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo
      4. Cardiac Transplantation and Prolonged Assisted Circulation  – Mandeep R. Mehra
      5. Aortic Valve ?Disease – Patrick T. O’Gara, Joseph Loscalzo
      6. Aortic Regurgitation  – Patrick T. O’Gara, Joseph Loscalzo
      7. Mitral Stenosis – Patrick T. O’Gara, Joseph Loscalzo
      8. Mitral Regurgitation – Patrick T. O’Gara, Joseph Loscalzo
      9. Mitral Valve Prolapse – Patrick T. O’Gara, Joseph Loscalzo
      10. Tricuspid Valve Disease – Patrick T. O’Gara, Joseph Loscalzo
      11. Pulmonic Valve Disease – Patrick T. O’Gara, Joseph Loscalzo
      12. Multiple and Mixed Valvular Heart Disease – Patrick T. O’Gara, Joseph Loscalzo
      13. Congenital Heart Disease in the Adult – Anne Marie Valente, Michael J. Landzberg
      14. Pericardial Disease – Eugene Braunwald
      15. Atrial Myxoma and Other Cardiac Tumors – Eric H. Awtry
    5. Section 5: Coronary and Peripheral Vascular Disease
      1. Ischemic Heart Disease – Elliott Antman, Joseph Loscalzo
      2. Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina) – Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald
      3. ST-Segment Elevation Myocardial Infarction – Elliott M. Antman, Joseph Loscalzo
      4. Percutaneous Coronary Interventions and Other Interventional Procedures – David P. Faxon, Deepak L. Bhatt
      5. Hypertensive Vascular Disease – Theodore A. Kotchen
      6. Renovascular Disease – Stephen C. Textor
      7. Deep Venous Thrombosis and Pulmonary Thromboembolism – Samuel Z. Goldhaber
      8. Diseases of the Aorta – Mark A. Creager, Joseph Loscalzo
      9. Arterial Diseases of the Extremities – Mark A. Creager, Joseph Loscalzo
      10. Chronic Venous Disease and Lymphedema  – Mark A. Creager, Joseph Loscalzo
      11. Pulmonary Hypertension – Aaron B. Waxman, Joseph Loscalzo
  9. Part 7: Disorders of the Respiratory System
    1. Section 1: Diagnosis of Respiratory Disorders
      1. Approach to the Patient with Disease of the Respiratory System – Patricia A. Kritek, Bruce D. Levy
      2. Disturbances of Respiratory Function – Edward T. Naureckas, Julian Solway 
      3. Diagnostic Procedures in Respiratory Disease – Anne L. Fuhlbrigge, Augustine M.K. Choi 
    2. Section 2: Diseases of the Respiratory System
      1. Asthma – Peter J. Barnes
      2. Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia – Praveen Akuthota, Michael E. Wechsler
      3. Occupational and Environmental Lung Disease – John R. Balmes
      4. Bronchiectasis – Rebecca M. Baron, Miriam Baron Barshak
      5. Cystic Fibrosis – Eric J. Sorscher
      6. Chronic Obstructive Pulmonary Disease – Edwin K. Silverman, James D. Crapo, Barry Make
      7. Interstitial Lung Disease – Gary M. Hunninghake, Ivan O. Rosas
      8. Disorders of the Pleura – Richard W. Light
      9. Disorders of the Mediastinum – Richard W. Light
      10. Disorders of Ventilation  – John F. McConville, Julian Solway, Babak Mokhlesi 
      11. Sleep Apnea – Andrew Wellman, Susan Redline
      12. Lung Transplantation – Elbert P. Trulock, III
  10. Part 8: Critical Care Medicine
    1. Section 1: Respiratory Critical Care
      1. Approach to the Patient with Critical Illness – John P. Kress, Jesse B. Hall
      2. Acute Respiratory Distress Syndrome – Rebecca M. Baron, Bruce D. Levy
      3. Mechanical Ventilatory Support – Bartolome R. Celli
    2. Section 2: Shock and Cardiac Arrest
      1. Approach to the Patient with Shock – Anthony F. Massaro
      2. Sepsis and Septic Shock – Christopher W. Seymour, Derek C. Angus
      3. Cardiogenic Shock and Pulmonary Edema – David H. Ingbar, Holger Thiele
      4. Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death  – Christine M. Albert, William G. Stevenson 
    3. Section 3: Neurologic Critical Care
      1. Coma – S. Andrew Josephson, Allan H. Ropper, Stephen L. Hauser 
      2. Severe Acute Encephalopathies and Critical Care Weakness – J. Claude Hemphill, III, Wade S. Smith, S. Andrew Josephson, Daryl R. Gress
      3. Subarachnoid Hemorrhage – J. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress
  11. Part 9: Disorders of the Kidney and Urinary Tract
    1. Cellular and Molecular Biology of the Kidney – Alfred L. George, Jr., Eric G. Neilson
    2. Acute Kidney Injury – Sushrut S. Waikar, Joseph V. Bonventre
    3. Chronic Kidney Disease  – Joanne M. Bargman, Karl L. Skorecki
    4. Dialysis in the Treatment of Renal Failure – Kathleen D. Liu, Glenn M. Chertow
    5. Transplantation in the Treatment of Renal Failure – Jamil Azzi, Edgar L. Milford, Mohamed H. Sayegh, Anil Chandraker 
    6. Glomerular Diseases – Julia B. Lewis, Eric G. Neilson
    7. Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development – Jing Zhou, Martin R.  Pollak
    8. Tubulointerstitial Diseases of the Kidney – Laurence H. Beck, Jr., David J. Salant
    9. Vascular Injury to the Kidney – Ronald S. Go, Nelson Leung
    10. Nephrolithiasis – Gary C. Curhan
    11. Urinary Tract Obstruction – Julian L. Seifter
  12. Part 10: Disorders of the Gastrointestinal System
    1. Section 1: Disorders of the Alimentary Tract
      1. Approach to the Patient with Gastrointestinal Disease – William L. Hasler, Chung Owyang
      2. Gastrointestinal Endoscopy – Louis Michel Wong Kee Song, Mark Topazian
      3. Diseases of the Esophagus – Peter J. Kahrilas, Ikuo Hirano
      4. Peptic Ulcer Disease and Related Disorders – John Del Valle
      5. Disorders of Absorption – Henry J. Binder
      6. Inflammatory Bowel Disease – Sonia Friedman, Richard S. Blumberg
      7. Irritable Bowel Syndrome – Chung Owyang
      8. Diverticular Disease and Common Anorectal Disorders – Rizwan Ahmed, Susan L. Gearhart
      9. Mesenteric Vascular Insufficiency – Satinderjit Locham, Mahmoud Malas
      10. Acute Intestinal Obstruction – Danny O. Jacobs
      11. Acute Appendicitis and Peritonitis – Danny O. Jacobs
    2. Section 2: Nutrition 
      1. Nutrient Requirements and Dietary Assessment – Johanna Dwyer
      2. Vitamin and Trace Mineral Deficiency and Excess – Paolo M. Suter, Robert M. Russell
      3. Malnutrition and Nutritional Assessment  – Gordon L. Jensen
      4. Enteral and Parenteral Nutrition – L. John Hoffer, Bruce R. Bistrian, David F. Driscoll
    3. Section 3: Liver and Biliary Tract Disease
      1. Approach to the Patient with Liver Disease – Marc G. Ghany, Jay H. Hoofnagle 
      2. Evaluation of Liver Function – Daniel S. Pratt
      3. The Hyperbilirubinemias – Allan W. Wolkoff
      4. Acute Viral Hepatitis – Jules L. Dienstag
      5. Toxic and Drug-Induced Hepatitis – William M. Lee, Jules L. Dienstag
      6. Chronic Hepatitis – Jules L. Dienstag
      7. Alcoholic Liver Disease – Mark E. Mailliard, Michael F. Sorrell
      8. Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis – Manal F. Abdelmalek, Anna Mae Diehl
      9. Cirrhosis and Its Complications – Bruce R. Bacon
      10. Liver Transplantation – Raymond T. Chung, Jules L. Dienstag
      11. Diseases of the Gallbladder and Bile Ducts – Norton J. Greenberger, Gustav Paumgartner
    4. Section 4: Disorders of the Pancreas
      1. Approach to the Patient with Pancreatic Disease – Darwin L. Conwell, Norton J. Greenberger, Peter A. Banks
      2. Acute and Chronic Pancreatitis – Darwin L. Co
Authors Biography

C.F. Kettering Professor of Medicine, Chief, Division of Endocrinology, Metabolism and Molecular Medicine Northwestern University Medical School, Chicago, IL.

Anthony S. Fauci, MD Chief, Laboratory of Immunoregulation, Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health. In 2008, Dr. Fauci was awarded the Presidential Medal of Freedom, the Nation’s highest civil award.

Dennis L. Kasper, MD, MA (Hon)William Ellery Channing Professor of Medicine, Professor of Microbiology and Molecular Genetics, Executive Dean for Academic Programs, Harvard Medical School, Director, Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital

Stephen L. Hauser, MD Chairman and Betty Anker Fife Professor, Department of Neurology, University of California, San Francisco

Dan L. Longo, MD Scientific Director, National Institute on Aging, National Institutes of Health, Bethesda, Maryland. Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Women’s Hospital, Boston, Massachusetts

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Weight 6.126 kg

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