Hoffbrand’s Essential Haematology (8th Edition)

Description

The new and fully updated edition of the definitive haematology textbook for undergraduate and postgraduate students and trainees

Hoffbrand’s Essential Haematology is widely regarded as the most authoritative introduction to the subject available, helping medical students and trainee doctors understand the essential principles of modern clinical and laboratory haematology for nearly four decades. Now in its eighth edition, this market-leading textbook introduces the formation and function of blood cells and the diseases that arise from dysfunction and disruption of these processes.

Beautifully presented with over 300 stunning colour illustrations, the new edition has been thoroughly updated to reflect recent advances in knowledge of the pathogenesis of blood diseases and their diagnosis and treatment. This new text:

• Describes disorders and diseases of the blood such as the various anaemias and white cell disorders, leukaemias, lymphomas and myeloma, as well as bleeding and thrombotic disorders
• Incorporates the latest World Health Organization (WHO) classification of haematological neoplastic diseases
• Reviews contemporary application of multiparameter flow cytometry, DNA sequencing and other technologies in evaluating patients with suspected haematological disease
• Discusses the therapeutic use of chimeric antigen T-cells, mono- and bi-specific monoclonal antibodies, inhibitors of intracellular signalling pathways and direct orally acting anticoagulants
• Includes sections on blood transfusion and the haematological aspects of systemic diseases, pregnancy and the neonate

Hoffbrand’s Essential Haematology is a vital resource for all students and trainees, and a valuable reference for practicing specialists wishing to update their knowledge.

Table of Contents

1. Preface to the Eighth Edition vi
2. Preface to the First Edition vii
3. How to use your textbook viii
4. About the companion website x
5. 1 Haemopoiesis 1
6. 2 Erythropoiesis and general aspects of anaemia 11
7. 3 Hypochromic anaemias 27
8. 4 Iron overload 42
9. 5 Megaloblastic anaemias and other macrocytic anaemias 50
10. 6 Haemolytic anaemias 64
11. 7 Genetic disorders of haemoglobin 78
12. 8 The white cells, part 1: granulocytes, monocytes and their benign disorders 96
13. 9 The white cells, part 2: lymphocytes and their benign disorders 111
14. 10 The spleen 126
15. 11 The aetiology and genetics of haematological neoplasia 132
16. 12 Management of haematological malignancy 147
17. 13 Acute myeloid leukaemia 158
18. 14 Chronic myeloid leukaemia 172
19. 15 Myeloproliferative neoplasms 182
20. 16 Myelodysplastic syndromes 196
21. 17 Acute lymphoblastic leukaemia 206
22. 18 The chronic lymphocytic leukaemias 219
23. 19 Hodgkin lymphoma 229
24. 20 Non-Hodgkin lymphomas 238
25. 21 Multiple myeloma and related plasma cell neoplasms 255
26. 22 Aplastic anaemia and bone marrow failure 272
27. 23 Haemopoietic stem cell transplantation 281
28. 24 Platelets, blood coagulation and haemostasis 296
29. 25 Bleeding disorders caused by vascular and platelet abnormalities 312
30. 26 Coagulation disorders 324
31. 27 Thrombosis 1: pathogenesis and diagnosis 338
32. 28 Thrombosis 2: treatment 347
33. 29 Haematological changes in systemic diseases 360
34. 30 Blood transfusion 372
35. 31 Pregnancy and neonatal haematology 386
36. Appendix 395
37. Index 401

Author Biography

Victor Hoffbrand is Emeritus Professor of Haematology, University College London and Honorary Consultant Haematologist, the Royal Free Hospital London, UK.

David Steensma is Associate Professor of Medicine at Harvard Medical School, and Haematologist and Oncologist at Dana-Farber Cancer Institute, Boston, USA.