Immunohistochemistry in Tumor Diagnostics

Description

This book offers a comprehensive yet concise overview of immunoprofile of tumors and antibodies used in contemporary surgical pathology, and provides diagnostic algorithms for approaching tumor diagnostics. Immunohistochemistry has become the most important ancillary technique in diagnostic pathology in the last 20 years, and unlike most books on tumor diagnostics, this volume discusses in details immunohistochemical biomarkers, diagnostic approaches and their pitfalls, as well as the immunoprofile of common tumors throughout all systems of human body. With numerous color figures and detailed flowcharts, it appeals to all pathologists be they young residents in training who want a brief introduction to this technique, or specialists in need of a reliable and comprehensive reference resource in tumors diagnostics.

Table of Contents

1. Immunohistochemistry in Tumor Diagnostics
2. Reference
3. Immunohistochemistry in Tumor Diagnostics
4. Expression Pattern and Diagnostic Pitfalls
5. Immunohistochemical Pathways for the Diagnosis Primary Tumors and of Metastasis of Unknown
6. References
7. Common Immunohistochemical Markers, Diagnostic approach, Pitfalls and Immunoprofiles of Most Common
8. Immunohistochemical Markers for the Diagnosis of Epithelial Tumors
9. Cytokeratins
10. Mucins
11. Claudins
12. Miscellaneous Epithelial Markers
13. References
14. Markers and Immunoprofile of the Upper Respiratory Tract and Pulmonary Tumors
15. Diagnostic Antibody Panel for Tumors of the Upper Respiratory Tract
16. Diagnostic Antibody Panel for Epithelial Pulmonary Tumors
17. Diagnostic Antibody Panel for Mesenchymal Pulmonary Tumors
18. References
19. Markers and Immunoprofile of Thymic Epithelial Tumors
20. References
21. Markers and Immunoprofile of Heart and Pericardial Tumors
22. Markers and Immunoprofile of Tumors of the Oral Cavity and Salivary Gland Tumors
23. Odontogenic Tumors and Tumors of the Oral Cavity
24. Salivary Gland Tumors
25. References
26. Markers and Immunoprofile of Tumors of the Gastrointestinal Tract
27. Gastrointestinal Epithelial Tumors
28. Diagnostic Antibody Panel for Gastrointestinal Carcinoma
29. Diagnostic Antibody Panel for Gastrointestinal Neuroendocrine Carcinoma
30. Gastrointestinal Mesenchymal Tumors
31. Diagnostic Antibody Panel for Gastrointestinal Stromal Tumors (GIST)
32. Diagnostic Antibody Panel for Miscellaneous Mesenchymal Gastrointestinal Tumors
33. References
34. Markers and Immunoprofile of Exocrine and Endocrine Pancreatic Tumors
35. Diagnostic Antibody Panel for Exocrine Pancreatic Tumors
36. Diagnostic Antibody Panel for Endocrine Pancreatic Tumors
37. References
38. Markers and Immunoprofile of Hepatobiliary Tumors
39. Hepatocellular Tumors
40. Cholangiocarcinoma
41. References
42. Markers and Immunoprofile of Breast Tumors
43. Diagnostic Antibody Panel for Breast Carcinoma
44. Diagnostic Antibody Panel for Fibroepithelial Tumors
45. Diagnostic Antibody Panel for Mesenchymal Tumors
46. References
47. Markers and Immunoprofile of Tumors of Female Reproductive Organs
48. Diagnostic Antibody Panel for Tumors of the Vulva and Vagina
49. Diagnostic Antibody Panel for Tumors of the Uterine Cervix
50. Diagnostic Antibody Panel for Epithelial Tumors of the Uterine Corpus, Fallopian Tube, and
51. Diagnostic Antibody Panel for Uterine Mesenchymal Tumors
52. Tumors of the Ovary
53. Diagnostic Antibody Panel for Ovarian Epithelial Tumors
54. Diagnostic Antibody Panel for Ovarian Germ Cell Tumors
55. Diagnostic Antibody Panel for Ovarian Sex Cord-Stromal Tumors
56. References
57. Markers and Immunoprofile of Renal and Urinary Tract Tumors
58. Renal Tumors
59. Urinary Tract Tumors
60. References
61. Markers and Immunoprofile of Male Genital Tract Tumors
62. Prostatic Tumors
63. Testicular and Paratesticular Tumors
64. Germ Cell Tumors
65. Sex Cord-Stromal Tumors
66. Paratesticular Tumors
67. References
68. Markers and Immunoprofile of Endocrine and Neuroendocrine Tumors
69. General Endocrine and Neuroendocrine Markers
70. Pituitary Gland Tumors
71. Diagnostic Antibody Panel for Tumors of the Anterior Pituitary Gland (Adenohypophysis)
72. Pituitary Hormones
73. Diagnostic Antibody Panel for Tumors of the Posterior Pituitary Gland (Neurohypophysis)
74. Tumors of the Thyroid Gland
75. Tumors of Follicular Cell Origin
76. Tumors of C-Cell Origin
77. Tumors of the Parathyroid Gland
78. Pancreatic Endocrine Tumors
79. Tumors of the Adrenal Gland
80. Diagnostic Antibody Panel for Adrenocortical Tumors
81. Markers and Immunoprofile of Tumors of Adrenal Medulla and Extra-adrenal Paraganglia
82. Diagnostic Antibody Panel for Pheochromocytoma and Extra-adrenal Paraganglia
83. Diagnostic Antibody Panel for Neuroblastoma and Extra-¬adrenal Paraganglia
84. Diagnostic Antibody Panel for Neuroendocrine Carcinomas (Small and Large Cell Types)
85. References
86. Markers and Immunoprofile of Mesothelioma Tumors of the Peritoneum
87. Diagnostic Antibody Panel for Mesothelial Tumors
88. Diagnostic Antibody Panel for Epithelial Tumors of Müllerian Type
89. Diagnostic Antibody Panel for Smooth Muscle Tumors
90. Diagnostic Antibody Panel for Tumors of Uncertain Origin and Miscellaneous Peritoneal Prima
91. References
92. Markers and Immunoprofile of Lymphoid Tissue Neoplasms
93. Screening Markers for Lymphoma
94. Markers and Immunoprofile of B-Cell Neoplasms
95. Markers and Immunoprofile of Plasma Cell Neoplasms
96. Markers and Immunoprofile of T-Cell Neoplasms
97. Markers and Immunoprofile of NK-Cell Neoplasms
98. Markers and Immunoprofile of Hodgkin’s Lymphoma
99. Diagnostic Antibody Panel for Classical Hodgkin’s Lymphoma
100. Diagnostic Antibody Panel for Nodular Lymphocyte-¬Predominant Hodgkin’s Lymphoma
101. References
102. Markers and Immunoprofile of Myeloid Neoplasm
103. References
104. Markers and Immunoprofile of Mastocytosis
105. References
106. Markers and Immunoprofile of Histiocytic and Dendritic Cell Tumors
107. References
108. Markers and Immunoprofile of Skin Tumors
109. References
110. Markers and Immunoprofile of Melanocytic Tumors
111. References
112. Markers and Immunoprofile of Fibroblastic, Myofibroblastic, and Fibrohistiocytic Tumors
113. References
114. Markers and Immunoprofile of Muscle Tumors
115. Diagnostic Antibody Panel for Skeletal Muscle Tumors
116. Diagnostic Antibody Panel for Smooth Muscle Tumors
117. References
118. Markers and Immunoprofile of Vascular and Perivascular Tumors
119. References
120. Markers and Immunoprofile of Adipocytic Tumors
121. References
122. Markers and Immunoprofile of Peripheral Nerve and Nerve Sheath Tumors
123. References
124. Markers and Immunoprofile of Central Nervous System Tumors
125. Diagnostic Antibody Panel for Tumors of the Central Nervous System
126. Diagnostic Antibody Panel for Meningeal Tumors
127. Markers and Immunoprofile of Ewing’s Sarcoma/Primitive Neuroectodermal Tumors (PNETs)
128. References
129. Markers and Immunoprofile of Extraskeletal Osseous and Cartilaginous Tumors
130. References
131. Markers and Immunoprofile of Miscellaneous Tumors and Tumors of Uncertain Differentiation
132. References
133. Markers to Assist the Diagnosis of Dysplasia and Malignant Transformation
134. Recommendations for the Utility of Immunohistochemistry in Tumor Diagnosis
135. Index

Authors Biography

Dr. Muin S.A. Tuffaha obtained a degree in general medicine with honors (MD) from the Medical Institute Kiev, UDSSR in 1986 before passing the German Board in Pathology. He continued as specialist in pathology at the Technical University of Dresden`s Institute of Pathology. Dr. Tuffaha was the deputy head of the Department of Head and Neck Pathology at the University of Hamburg. Since 2010, Dr. Tuffaha has been head at the Institute of Pathology, Carl-Thiem-Hospital a teaching hospital of the Medical Faculty Charité, Berlin, Germany. He received an honorary Professor from the Kiev Medical University of UAFM.

Professor Hans Guski is Professor of Pathology and the former Deputy Director of the Institute of Pathology of the Humboldt University of, where he worked for more than 40 years. During this time, he mentored about 70 doctoral candidates and published over 500 scientific articles and presented papers. He is co-author of several textbooks and monographs, including a monograph on immunohistochemical studies in tumors published in Russian by Dr. Tuffaha (Kiev 2013). Professor Guski has been an ordinary member of the Russian Academy of Natural Sciences since 1992 and is an honorary member of several international medical societies. He received an honorary doctorate from the State University of Saransk, Russia, in 1996, and has been a Guest Professor of the University of Havana, Cuba, since 2004.
Professor Glen Kristiansen has been a professor of pathology and chair of the Institute of Pathology, University Bonn, Germany since 2011. From 2007 to 2011, he was a professor of molecular tumor pathology and head of the Immunohistochemistry Laboratory at the Institute of Surgical Pathology, University Zurich, Switzerland. He was also resident and later consultant and head of the Immunohistochemistry Laboratory at the Institute of Pathology, Charité, Berlin, Germany (1998-2007). In 2014, he broadened his skills at the Cedars-Sinai Hospital Medical Center, Los Angeles, USA. Professor Kristiansen has authored or co-authored more than 300 scientific publications and is an acclaimed speaker at international congresses.