ISE Harper’s Illustrated Biochemistry (31st Edition)

Description

Gain a full understanding of the principles of biochemistry as it relates to clinical medicine

A Doody’s Core Title for 2019! 

The Thirty-First Edition of Harper’s Illustrated Biochemistry continues to emphasize the link between biochemistry and the understanding of disease states, disease pathology, and the practice of medicine. Featuring a full-colour presentation and numerous medically relevant examples, Harper’s presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.

All 58 chapters help you understand the medical relevance of biochemistry

• Full-colour presentation includes more than 600 illustrations
• Case studies emphasize the clinical relevance of biochemistry
• NEW CHAPTER on Biochemistry of Transition Metals addresses the importance and overall pervasiveness of  transition metals
• Review Questions follow each of the eleven sections
• Boxed Objectives define the goals of each chapter
• Tables encapsulate important information
• Every chapter includes a section on the biomedical importance of a given topic

New to this Edition

• Emphasis throughout on the integral relationship between biochemistry and disease, diagnostic pathology, and medical practice
• Hundreds of references to disease states throughout
• New chapter addressing the biochemical roles of transition metals
• Many updated review questions
• Frequent tables summarizing key links to disease states
• New text on cryo-electron microscopy (cryo-EM)
• Cover picture of the protein structure of the Zika virus, solved by cryo-EM
  

Applauded by medical students and online reviewers for its currency and engaging style, Harper’s Illustrated Biochemistry is essential for USMLE® review and the single-best reference for learning the clinical relevance of any biochemistry topic.

Table of Contents

1. Section I: Structures & Functions of Proteins & Enzymes
   1. Chapter 1: Biochemistry & Medicine
   2. Chapter 2: Water & pH
   3. Chapter 3: Amino Acids & Peptides
   4. Chapter 4: Proteins: Determination of Primary Structure
   5. Chapter 5: Proteins: Higher Orders of Structure
2. Section II: Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals
   1. Chapter 6: Proteins: Myoglobin & Haemoglobin
   2. Chapter 7: Enzymes: Mechanism of Action
   3. Chapter 8: Enzymes: Kinetics
   4. Chapter 9: Enzymes:Regulation of Activities
   5. Chapter 10: The Biochemical Roles of Transition Metals
3. Section III: Bioenergetics
   1. Chapter 11: Bioenergetics: The Role of ATP
   2. Chapter 12: Biologic Oxidation
   3. Chapter 13: The Respiratory Chain & Oxidative Phosphorylation
4. Section IV: Metabolism of Carbohydrates
   1. Chapter 14: Overview of Metabolism & the Provision of Metabolic Fuels
   2. Chapter 15:Carbohydrates of Physiological Significance
   3. Chapter 16: The Citric Acid Cycle: The Central Pathway of Carbohydrate, Lipid, & Amino Acid Metabolism
   4. Chapter 17: Glycolysis & the Oxidation of Pyruvate
   5. Chapter 18: Metabolism of Glycogen
   6. Chapter 19: Gluconeogenesis & the Control of Blood Glucose
   7. Chapter 20: The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism
5. Section V: Metabolism of Lipids
   1. Chapter 21: Lipids of Physiologic Significance
   2. Chapter 22: Oxidation of Fatty Acids: Ketogenesis
   3. Chapter 23: Biosynthesis of Fatty Acids & Eicosanoids
   4. Chapter 24: Metabolism of Acylglycerols & Sphingolipids
   5. Chapter 25: Lipid Transport & Storage
   6. Chapter 26: Cholesterol Synthesis, Transport, & Excretion
6. Section VI: Metabolism of Proteins & Amino Acids
   1. Chapter 27: Biosynthesis of the Nutritionally Nonessential Amino Acids
   2. Chapter 28: Catabolism of Proteins & of Amino Acid Nitrogen
   3. Chapter 29: Catabolism of the Carbon Skeletons of Amino Acids
   4. Chapter 30: Conversion of Amino Acids to Specialized Products
   5. Chapter 31: Porphyrins & Bile Pigments
7. Section VII: Structure, Function, & Replication of Informational Macromolecules
   1. Chapter 32: Nucleotides
   2. Chapter 33: Metabolism of Purine & Pyrimidine Nucleotides
   3. Chapter 34: Nucleic Acid Structure & Function
   4. Chapter 35: DNA Organisation, Replication, & Repair
   5. Chapter 36: RNA Synthesis, Processing, & Modification
   6. Chapter 37: Protein Synthesis & the Genetic Code
   7. Chapter 38: Regulation of Gene Expression
   8. Chapter 39: Molecular Genetics, Recombinant DNA, & Genomic Technology
8. Section VIII: Biochemistry of Extracellular & Intracellular Communication
   1. Chapter 40: Membranes: Structure & Function
   2. Chapter 41: The Diversity of the Endocrine System
   3. Chapter 42: Hormone Action & Signal Transduction
9. Section IX: Special Topics (A)
   1. Chapter 43: Nutrition, Digestion, & Absorption
   2. Chapter 44: Micronutrients: Vitamins & Minerals
   3. Chapter 45: Free Radicals & Antioxidant Nutrients
   4. Chapter 46: Glycoproteins
   5. Chapter 47: Metabolism of Xenobiotics
   6. Chapter 48: Clinical Biochemistry
10. Section X: Special Topics (B)
    1. Chapter 49: Intracellular Traffic & Sorting of Proteins
    2. Chapter 50: The Extracellular Matrix
    3. Chapter 51: Muscle& the Cytoskeleton
    4. Chapter 52: Plasma Proteins & Immunoglobulins
    5. Chapter 53: Red Blood Cells
    6. Chapter 54: White Blood Cells
11. Section XI: Special Topics (C)
    1. Chapter 55: Haemostasis & Thrombosis
    2. Chapter 56: Cancer: An Overview
    3. Chapter 57: The Biochemistry of Aging
    4. Chapter 58: Biochemical Case Histories