Medical Biochemistry (5th Edition)

Description

Now fully revised, this acclaimed textbook efficiently links basic biochemistry with the day-to-day practice of medicine. You will learn basic science concepts and see them illustrated by clinical cases that describe patients you will likely encounter in your clinical training. You will also learn about the use of laboratory tests to diagnose and monitor the most important conditions. Brought to you in a thorough yet accessible manner, this new edition of Medical Biochemistry highlights the latest developments in regulatory and molecular biology, signal transduction, biochemistry and biomarkers of chronic disease, and bioinformatics and the ‘-omics’. It highlights the most important global medical issues: diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and addresses the role of nutrition and exercise in medicine.

Key Features

• Featuring a team of expert contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this book offers a unique combination of research and clinical practice tailored to today’s integrated courses.
• Read organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused ones addressing the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer.

Table of Contents

1. Section 1: Introduction
   1. Chapter 1 : Introduction
2. Section 2: Molecules and Cells
   1. Chapter 2 : Amino Acids and Proteins
   2. Chapter 3 : Carbohydrates and Lipids
   3. Chapter 4 : Membranes and Transport
3. Section 3: Metabolism
   1. Chapter 5 : Hemoglobin and oxygen transport
   2. Chapter 6 : Catalytic Proteins – Enzymes
   3. Chapter 7 : Vitamins and Minerals
   4. Chapter 8 : Bioenergetics and Oxidative Metabolism
   5. Chapter 9 : Anaerobic metabolism of glucose carbohydrates in the red blood cell
   6. Chapter 10: The Tricarboxylic Acid Cycle
   7. Chapter 11: Oxidative Metabolism of Lipids in Liver and Muscle
   8. Chapter 12 : Biosynthesis and Storage of Carbohydrates in Liver and Muscle
   9. Chapter 13: Biosynthesis and Storage of Fatty Acids
   10. Chapter 14: Biosynthesis of Cholesterol and Steroids
   11. Chapter 15: Biosynthesis and Degradation of Amino Acids
   12. Chapter 16: Biosynthesis and Degradation of Nucleotides
   13. Chapter 17: Complex Carbohydrates: Glycoproteins
   14. Chapter 18: Complex Lipids
   15. Chapter 19: The Extracellular Matrix
4. Section 4: Molecular basis of inheritance
   1. Chapter 20: Deoxyribonucleic Acid
   2. Chapter 21: Ribonucleic Acid
   3. Chapter 22: Protein Synthesis and Turnover
   4. Chapter 23: Regulation of Gene Expression: Basic Mechanisms
   5. Chapter 24: Genomics, Proteomics and Metabolomics
5. Section 5: Signalling and Growth
   1. Chapter 25: Membrane Receptors and Signal Transduction
   2. Chapter 26: Neurotransmitters
   3. Chapter 27: Biochemical Endocrinology
   4. Chapter 28: Cellular Homeostasis: Cell Growth and Cancer
   5. Chapter 29: Aging
6. Section 6: Fuels Nutrients and Minerals
   1. Chapter 30: Digestion and Absorption of Nutrients: The Gastrointestinal Tract
   2. Chapter 31: Glucose Homeostasis and Fuel Metabolism: Diabetes Mellitus
   3. Chapter 32: “Nutrients and diets”
   4. Chapter 33: Lipoprotein Metabolism and Atherogenesis
7. Section 7: Specialized Tissues and Their Function
   1. Chapter 34: The Role of Liver in Metabolism
   2. Chapter 35: Water and Electrolytes Homeostasis
   3. Chapter 36: Lung and the Regulation of Hydrogen Ion Concentration (Acid-Base Balance)
   4. Chapter 37: Muscle: Energy Metabolism and Contraction Exercise
   5. Chapter 38: Bone Metabolism and Calcium Homeostasis
   6. Chapter 39: Neurochemistry
8. Section 8: Blood and Immunity.
   1. Clinical Biochemistry
   2. Chapter 40: Blood and Plasma Proteins
   3. Chapter 41: Haemostasis and Thrombosis
   4. Chapter 42: Oxidative stress and inflammation
   5. Chapter 43: The Immune Response: Innate and adaptive immunity
9. Appendix 1: Selected Clinical laboratory reference ranges
10. Appendix 2: Case Studies

Authors Biography

John Baynes

Affiliations and Expertise
Carolina Distinguished Professor Emeritus; Department of Pharmacology, Physiology and Neuroscience; University of South Carolina School of Medicine; Columbia, South Carolina

Marek Dominiczak

Affiliations and Expertise
Honorary Professor of Clinical Biochemistry and Medical Humanities, University of Glasgow; Consultant Biochemist, NHS Greater Glasgow and Clyde, Glasgow, UK