Neonatal and Paediatric Prescribing

Description

Your guide to delivering safe and effective medicines for children

Prescribing Medicines for Children covers a broad range of important topics in paediatric therapeutics, ranging from the principles of clinical pharmacology in children through to medication safety and drug development.

It is an international title that provides guidance on the principles behind optimal neonatal and paediatric prescribing globally.

The book is divided into two parts. Part I provides concise educational material relating to paediatric clinical pharmacology and optimising how medicines are developed and prescribed for children. It covers research methods for investigating paediatric medicines, from clinical trials through to pharmacoepidemiology and medicinal formulations.

Part II considers key clinical prescribing areas and can be used as a quick reference guide. Each chapter is focused on the key issues in prescribing for a respective clinical specialty or context, with a broad range of subjects from core topics of General Paediatrics through to Paediatric Intensive Care.

This book complements British National Formulary for Children (BNFC).

Prescribing Medicines for Children is indispensable reference guide for anyone involved in prescribing medicines to neonates and children. This includes undergraduate and postgraduate pharmacists, nurses, paediatricians and primary care physicians, academic scientists, and those working in the pharmaceutical industry and drug regulation.

Table of Contents

1.  PART I
   1. General principles of paediatric clinical pharmacology 1
   2. Pharmacokinetics: an overview 7
   3. Drug absorption 13
   4. Drug distribution: from birth to adolescence 19
   5. Drug metabolism 25
   6. Drug elimination 31
   7. Pharmacodynamics: practical examples 37
   8. Pharmacogenetics and pharmacogenomics 43
   9. Modelling and simulation: pharmacometrics 49
   10. Adverse drug reactions 57
   11. Drug interactions 65
   12. Pregnancy and lactation 71
   13. Paediatric clinical pharmacology 77
   14. Education: training programmes and competencies 83
   15. The paediatric drug discovery pipeline 91
   16. Understanding phase I clinical trials 101
   17. Early phase clinical trials: adaptive designs 109
   18. Phase IV studies and pharmacovigilance 119
   19. Non-interventional studies 123
   20. Pharmacoepidemiology 131
   21. Innovative strategies in paediatric drug development 137
   22. The role of the pharmaceutical industry in developing
   23. medicines for children 149
   24. Paediatric drug formulations 157
   25. Extemporaneous preparations of medicines for children 163
   26. Excipients in medicines for children 171
   27. The role of parents and children in paediatric medicines
   28. research 179
   29. The ethics of medicines research in children 187
   30. Evidence-based prescribing 195
   31. Improving training in prescribing 201
   32. Electronic prescribing 211
   33. Avoiding medication errors 219
   34. Intravenous medicines administration 225
   35. Team working in medicines administration 233
   36. Evidence-based formularies 241
   37. Therapeutic drug monitoring 247
   38. Medicines for children in low to middle income countries 255
   39. Optimal prescribing in the resource-poor setting 265
2. PART II
   1. Gastrointestinal system 273
   2. Cardiovascular system 287
   3. Respiratory system 297
   4. Antiepileptic drug therapy 305
   5. Prescribing in infection: anti bacterials 319
   6. Prescribing in infection: antifungals and antivirals 339
   7. Endocrinology 353
   8. Diabetes mellitus 369
   9. Adolescent medicine 383
   10. Nephrology 391
   11. Prescribing blood and blood components 399
   12. Oncology: cytotoxic drugs 409
   13. Immunosuppressive agents in paediatric solid organ
   14. transplantation 423
   15. Nutrition and metabolism 431
   16. Rheumatology 443
   17. Ophthalmology 455
   18. Ear, nose and throat disorders 471
   19. Medical therapy in dermatology 481
   20. Immunological products 495
   21. Prescribing vaccines: an overview 503
   22. Sedation and anaesthesia 513
   23. Palliative care 523
   24. Pain management 535
   25. Drugs and pharmacology in paediatric intensive care 547