Neurologic Disease: a Modern Pathophysiologic Approach to Diagnosis and Treatment

Description

This novel title explores the central and peripheral nervous system in health and disease. By first establishing a fundamental basic science knowledge about the cellular elements of the nervous system, the reader is then presented with clinical cases in a pathophysiologic manner, as exemplified in unifying Guillain Barre and Multiple Sclerosis in one chapter on Demyelinating Disease. The reader is encouraged to adopt a systematic approach of sorting out neurologic problems he or she may face in clinical practice by identifying time and space factors based on the age of a patient. High quality illustrations for each case are included in the book along with novel three-dimensional reconstructions of MR, PET, and CT data whenever possible. Developed largely for medical students as an introduction to the clinical neurosciences, for neurology residents, and for others doing graduate level neuroscience study, Neurology – A Modern, Pathophysiologic Approach to the Diagnosis and Treatment of Neurologic Disease will also be of significant interest to the established neurologist as a comprehensive, up-to-date reference.

Table of Contents

1. Introduction to Differential Diagnosis in Neurology
2. General Principles
3. Organizational Principles
4. Neurological Diagnosis
5. Formulation of a Diagnosis
6. Systematic Approach to Neurological Problems
7. Diagnosis by Time and Space Factors (Table 1.2)
8. Clinical Examples Using the Age, Time, and Space Algorithm Approach
9. Diagnosis: Signs and Symptoms
10. Organizational Overview of the Text
11. Forming a Diagnosis: Acute Versus Chronic, Focal Versus Diffuse
12. Examples of Disease Affecting Fundamental Units of Neurologic Functioning
13. An Incremental Segmental Approach to the Central Versus Peripheral Nervous System
14. Clinical Examples of Disease at Each Anatomic Level
15. Neurologic Disease Is Very Prevalent
16. Data for USA in 2005
17. Prevalence
18. Incidence [2]
19. Neurological Emergencies (Table 1.3)
20. Cellular and Subcellular Elements of the Nervous System
21. Stroke
22. Introduction
23. General Facts About Stroke
24. Establishing a Stroke Diagnosis
25. Historical Aspects of Cerebrovascular Disease
26. Modern Concepts in Cerebrovascular Anatomy and Disease
27. Acute Management Issues with ICH
28. Cerebral Aneurysms
29. Hypertension-Related Intracranial Hemorrhage
30. Intracranial Hemorrhage: Relation to Thrombocytopenia
31. Facts on TIA
32. Thrombolytic Therapy
33. Clinical Analysis by Time and Space Methodology
34. Details of the Ninds Stroke Protocol (Fig. 3.41)
35. Stroke in Young Adults
36. IV tPA Contraindicated with Anticoagulation
37. Common Normal Developmental Variations
38. New Developments in Acute Stroke Care
39. Stroke in Special Populations
40. Seasonal Fluctuations in Stroke Mortality
41. Circadian Variation in the Timing of Stroke Onset
42. CT Angiography in the Management of Carotid Disease
43. Circle of Willis Is Crucial in Maintaining Flow in Setting of Unilateral ICA Disease
44. Functional Recovery After Stroke: New Insights Using MRI and PET
45. Epilepsy
46. Introduction
47. Historical Aspects of Epilepsy
48. Demyelinating Diseases of the Peripheral and Central Nervous System: Guillain–Barre and Mul
49. Introduction
50. Guillain–Barre Syndrome or Acute Inflammatory Demyelinating Polyneuropathy
51. Multiple Sclerosis
52. Leukodystrophies and Other Diseases of the White Matter
53. The Hippocampus
54. Introduction
55. Clinical Case Examples
56. Alzheimer’s Disease
57. Clinical and Radiographic Aspects of Alzheimer’s Disease
58. Neurodegenerative Diseases
59. Diseases of Skeletal Muscle
60. Introduction
61. Diseases of the Spinal Cord
62. The Cerebellum
63. Introduction
64. The Visual Cortex
65. Migraine and the Occipital Cortex
66. Infections of the Nervous System
67. Neoplastic Diseases
68. Radiation Necrosis
69. Genetic Defects and Primary Neoplasms
70. Traumatic and Toxic Effects on the Nervous System
71. Toxins and the Nervous System: Alcohol, Mercury, Lead, Medications
72. Conclusions
73. Introduction

Editor Biography

Michael Andrew Meyer is Editor-In-Chief for NEUROLOGY INTERNATIONAL and currently serves as co-director of Neurosciences for the Guthrie Clinic after being the Medical Director for Neurology and Stroke Services for Sisters Hospital and the St. Joseph’s Hospital Campus, Buffalo, NY. Dr. Meyer was a Principal Investigator for the NINDS tPA trial and co-authored the landmark New England Journal of Medicine article on tPA for acute stroke. Prior to directing Neurological Services for Tennova Health Care, Dr. Meyer was a member of the Acute Stroke Team for Catholic Health in Buffalo NY and had served as Chief of Neurology and Stroke Services for the Erie County Medical Center in Buffalo. As former Neurology Residency Program Director for the University at Buffalo School of Medicine where he served as Professor of Clinical Neurology and Nuclear Medicine, Dr. Meyer has trained and mentored numerous physicians in the field of Neurology. At the University of Michigan, Dr. Meyer studied GABA receptors in Alzheimer’s Disease and concluded they were preserved, even in areas of dysfunctional posterior parietal cortex. As the Cole Neuroscience Foundation Investigator at the University of Tennessee, Dr. Meyer conducted some of the earliest studies on the use of PET in acute stroke, and developed techniques for PET radio-nuclide angiography, and made the first auto-radiographic demonstration of magnetic reduction of positron range, and later performed original research on the potential use of positron emitters for tumor radiotherapy.