Obesity, Type 2 Diabetes and the Adipose Organ | KitaabNow

Obesity, Type 2 Diabetes and the Adipose Organ


A Pictorial Atlas from Research to Clinical Applications

  • Author: Saverio Cinti
  • ISBN: 9783319405209
  • Publisher: Springer Publishing Company
  • Edition: 2nd
  • Publication Date: March 8, 2018
  • Format: Hardback – 455 pages
  • Language: English

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This richly illustrated book provides a detailed description of the gross anatomy, light microscopy, immunohistochemistry, and electron microscopy of the adipose organ, which comprises subcutaneous and visceral fat depots. Findings in mice of differing genetic backgrounds (obesity prone and resistant) and maintained in standard and various physiologic and pathologic conditions are presented. The latter conditions include chronic cold exposure, warm exposure, fasting, pregnancy–lactation, and obesity. Features of the fetal adipose organ are described in a separate chapter, and results from transgenic mice are also presented when relevant.

The human adipose organ is addressed in several chapters that include magnetic resonance and fetal findings. Most of the results regarding the adipose organ anatomy in different physiologic conditions are new, and the story of pink adipocytes (white-to-pink transdifferentiation) is quite innovative. The concept of using browning of the adipose organ as a therapeutic tool for obesity must take into consideration the anatomic and morphologic aspects described here, and the study of pink adipocytes could lead to a better comprehension of breast cancer tumor biology. This book will be of interest to all scientists who deal with obesity and related disorders.

Key Features
  • Describes anatomic and morphologic aspects of adipose tissues relevant to obesity therapy
  • Presents new results regarding adipose organ anatomy in different physiologic conditions
  • Introduces white-to-pink transdifferentiation of adipocytes and its implications
Table of Contents
  1. The Adipose Organ
  2. Brown Adipose Tissue (BAT)
  3. White Adipose Tissue (WAT)
  4. The Adipose Organ: Cold Acclimation
  5. BAT
  6. WAT
  7. The Adipose Organ: Warm Acclimation: BAT
  8. The Obese Adipose Organ: BAT
  9. The Fasted Adipose Organ: WAT
  10. BAT
  11. The Adipose Organ During Lactation: WAT
  12. BAT
  13. The Fetal Adipose Organ
  14. The Adipose Organ In Genetically Modified Models
Author Biography

Saverio Cinti, MD, graduated from the University of Padua, Italy, in 1974 and subsequently completed specializations in Internal Medicine (University of Verona) and Surgical Pathology (University of Milan). In 1986 he was appointed Full Professor of Human Anatomy at the University of Ancona. Dr. Cinti is currently President of the Obesity Center at the University of Ancona and Director of the Biology of Obesity Unit at United Hospitals of Ancona. He has also been a Visiting Professor at Harvard Medical School (Elio Raviola lab)

Additional information
Weight 1.886 kg

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