Pathophysiology: The Biologic Basis for Disease in Adults and Children (8th Edition)

Description

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 8th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW chapter on obesity and nutritional disorders, along with expanded coverage of rare diseases and epigenetics. It’s the most comprehensive and authoritative pathophysiology text available!

Key Features

• The most comprehensive and authoritative pathophysiology text on the market provides unparalleled coverage of Pathophysiology content.
• Over 1,300 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes — more than in any other pathophysiology text.
• Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment.
• Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content.
• Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition.
• Algorithms and flowcharts of diseases and disorders make it easy for you to follow the sequential progression of disease processes.
• Additional What’s New boxes highlight the most current research and clinical development.
• Nutrition and Disease boxes explain the link between concepts of health promotion and disease.
• Chapter summary reviews provide concise synopses of the main points of each chapter.

New to this Edition

• NEW! Chapter on obesity and nutritional disorders thoroughly covers these growing global concerns.
• NEW! Added coverage of rare diseases and epigenetics further explore genetic disease traits.
• NEW! Over 50 new or heavily revised illustrations visually highlight pathophysiology concepts.
• NEW! More than 30 new 3D animations on Evolve bring difficult concepts to life for a new perspective on disease processes.

Table of Contents

1. Part 1: CENTRAL CONCEPTS OF PATHOPHYSIOLOGY: CELLS AND TISSUES
2. Unit I: THE CELL
   1. Cellular Biology
   2. Altered Cellular and Tissue Biology: Environmental Agents
   3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases
3. Unit II: GENES AND GENE-ENVIRONMENT INTERACTION
   1. Genes and Genetic Diseases
   2. Genes, Environment-Lifestyle, and Common Diseases
   3. Epigenetics and Disease
4. Unit III: MECHANISMS OF SELF-DEFENSE
   1. Innate Immunity: Inflammation
   2. Adaptive Immunity
   3. Alterations in Immunity and Inflammation
   4. Infection
   5. Stress and Disease
5. Unit IV. CELLULAR PROLIFERATION: CANCER
   1. Cancer Biology
   2. Cancer Epidemiology
   3. Cancer in Children
6. Part 2: PATHOPHYSIOLOGIC ALTERATIONS: ORGANS AND SYSTEMS
7. Unit V: THE NEUROLOGIC SYSTEM
   1. Structure and Function of the Neurologic System
   2. Pain, Temperature Regulation, Sleep, and Sensory Function
   3. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
   4. Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction
   5. Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders
   6. Alterations of Neurologic Function in Children
8. Unit VI: THE ENDOCRINE SYSTEM
   1. Mechanisms of Hormonal Regulation
   2. Alterations of Hormonal Regulation
   3. Obesity and Disorders of Nutrition NEW
9. Unit VII: THE REPRODUCTIVE SYSTEMS
   1. Structure and Function of the Reproductive Systems
   2. Alterations of the Female Reproductive System
   3. Alterations of the Male Reproductive System
   4. Sexually Transmitted Infections
10. Unit VIII: THE HEMATOLOGIC SYSTEM
    1. Structure and Function of the Hematologic System
    2. Alterations of Erythrocyte, Platelet, and Hemostatic Function
    3. Alterations of Leukocyte and Lymphoid Function
    4. Alterations of Hematologic Function in Children
11. Unit IX: THE CARDIOVASCULAR AND LYMPHATIC SYSTEMS
    1. Structure and Function of the Cardiovascular and Lymphatic Systems
    2. Alterations of Cardiovascular Function
    3. Alterations of Cardiovascular Function in Children
12. Unit X: THE PULMONARY SYSTEM
    1. Structure and Function of the Pulmonary System
    2. Alterations of Pulmonary Function
    3. Alterations of Pulmonary Function in Children
13. Unit XI: THE RENAL AND UROLOGIC SYSTEMS
    1. Structure and Function of the Renal and Urologic Systems
    2. Alterations of Renal and Urinary Function
    3. Alterations of Renal and Urinary Tract Function in Children
14. Unit XII: THE DIGESTIVE SYSTEM
    1. Structure and Function of the Digestive System
    2. Alterations of Digestive Function
    3. Alterations of Digestive Function in Children
15. Unit XIII: THE MUSCULOSKELETAL SYSTEM
    1. Structure and Function of the Musculoskeletal System
    2. Alterations of Musculoskeletal Function
    3. Alterations of Musculoskeletal Function in Children
16. Unit XIV: THE INTEGUMENTARY SYSTEM
    1. Structure, Function, and Disorders of the Integument
    2. Alterations of the Integument in Children
17. Unit XV: MULTIPLE INTERACTING SYSTEMS
    1. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults
    2. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

Authors Biography

Kathryn L. McCance, MS, PhD, Professor, College of Nursing, University of Utah, Salt Lake City, UT and

Sue E. Huether, MS, PhD, Professor Emeritus, College of Nursing, University of Utah, Salt Lake City, UT