Patient-Derived Xenograft Models of Human Cancer | KitaabNow

Patient-Derived Xenograft Models of Human Cancer

  • Edited by: Yuzhuo Wang, Dong Lin, Peter W. Gout
  • ISBN: 9783319558240
  • Publisher: Springer Publishing Company
  • Edition: 1st
  • Publication Date: August 1, 2017
  • Format: Hardback – 204 Pages
  • Language: English


This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text.

Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.

Key Features
  • Provides a comprehensive, state-of-the art review of PDX cancer models
  • Written by world-renowned experts in the field
  • Provides interactivity through extensive illustrations
Table of Contents
  1. Section I: Introduction
    1. History and Evolution of PDX Cancer Models
  2. Section II: Establishment and Characterization of PDX Models
    1. Methods of Generating PDX Models
    2. Fidelity and Stability of PDX Models
  3. Section III: Applications of PDX Models
    1. Studies of Cancer Heterogeneity
    2. PDX and Cancer Stem Cells
    3. Modeling Cancer Metastasis
    4. Modeling Drug Resistance
    5. PDX and Biomarker Development
    6. PDX and Preclinical Drug Screening
    7. Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine
  4. Section IV: Epilogue
    1. Future Perspective
Authors Biography

Yuzhuo Wang, PhD Director, Living Tumor Laboratory Distinguished Scientist, BC Cancer Agency

Senior Scientist, Vancouver Prostate Centre

Professor, University of British Columbia

Dong Lin, PhD, MD Research Pathologist, Living Tumor Laboratory

Peter W. Gout, PhD Scientific Consultant, Living Tumor Laboratory

Honorary Associate Professor, Department of Urologic Sciences, University of British Columbia

Emeritus Senior Scientist, Department of Experimental Therapeutics, BC Cancer Agency

Additional information
Weight4.489 kg

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