Prion Diseases | KitaabNow

Prion Diseases

  • Edited By: Pawel P. Liberski
  • ISBN: 9781493972098
  • Publisher: Springer Publishing Company
  • Edition: 1st
  • Publication Date: September 1, 2017
  • Format: Hardback – 304 Pages
  • Language: English


This volume provides comprehensive information and detailed laboratory protocols used in the study of prion diseases. The chapters in this book cover topics such as: electron microscopy, neuropathology, immunohistochemistry, and immune-gold electron microscopy of prion diseases. Chapters also provide readers with detailed information about kuru, the clinical description of prion diseases, and the detection of prion protein and biomarkers. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and authoritative, Prion Diseases is a valuable resource for researchers and scientists in the exciting and rapidly growing field of prion disease research.

Key Features
  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
Table of Contents
  1. Series Preface
  2. Dedication
  3. Preface
  4. Table of Contents
  5. Contributing Authors
  6. Kuru: Introduction to Prion Diseases By Pawel P. Liberski, Agata Gajos, and Beata Sikorska
  7. Anthropological Methods used in Kuru Research By Shirley Lindenbaum
  8. Nonhuman Primates in Research on Transmissible Spongiform Encephalopathies By David M. Asher, Pedro Piccardo, and Luisa Gregori
  9. Clinical Features and Diagnosis of Human Prion Diseases By Richard Knight
  10. Neuropathology, Immunohistochemistry, and Biochemistry in Human Prion Diseases By Diane L. Ritchie and James W. Ironside
  11. Sub-Cellular and Molecular Changes Associated with Abnormal PrP Accumulation in Brain and Viscera of Classical and Atypical Prion Diseases By Martin Jeffrey and Gillian McGovern
  12. Electron Microscopy of Prion Diseases By Pawel P. Liberski
  13. Cell Death and Autophagy in Prion Diseases By Pawel P. Liberski
  14. Methods for Isolation of Spiroplasma sp. from Prion Positive Eye Tissues of Sheep Affected with Terminal Scrapie By Frank O. Bastian
  15. Detection and Diagnosis of Prion Diseases using RT-QuIC: An Update By Byron Caughey, Christina D. Orru, Bradley R. Groveman, Matilde Bongianni, Andrew G. Hughson, Lynne D. Raymond, Matteo Manca, Allison Kraus, Gregory J. Raymond, Michele Fiorini, Maurizio Pocchiari, and Gianluigi Zanusso
  16. Analysis of Charge Isoforms of the Scrapie Prion Protein using Two-Dimensional Electrophoresis By Elizaveta Katorcha and Ilia V. Baskakov
  17. Exosomes in Prion Diseases By Alexander Hartmann, Hermann Altmeppen, Susanne Krasemann, and Markus Glatzel
  18. Synthetic Mammalian Prions By Fabio Moda, Edoardo Bistaffa, Joanna Narkiewicz, Giulia Salzano, and Giuseppe Legname
  19. Biomarkers in Cerebrospinal Fluid By Joanna Gawinecka, Matthias Schmitz, and Inga Zerr
  20. The Use of Transgenic and Knock Out Mice in Prion Research By Abigail B. Diack and Jean C. Manson
  21. Transgenic Mouse Models of Prion Diseases By Julie Moreno and Glenn C. Telling
Additional information
Weight 7.466 kg

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