Rang & Dale’s Pharmacology, International Edition (9th Edition)

Description

Comprehensive yet easy to use, Rang and Dale’s Pharmacology has been providing core basic and clinical science information to students and healthcare practitioners worldwide for more than 25 years. The fully revised 9th Edition keeps you up to date with all that’s new in the field, including new and emerging drugs and recent studies. From cover to cover, you’ll progressively increase your knowledge of all relevant aspects of pharmacology, from a molecular understanding of receptors and drug actions through clinical uses of key groups of drugs.

Key Features

• Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more.
• Includes access to unique features online, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment.
• Features a color-coded layout for faster navigation and cross-referencing.
• Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout.

Table of Contents

1. Rang and Dale’s Pharmacology
2. Section 1. General principles
   1. What is pharmacology?
   2. How drugs act: general principles
   3. How drugs act: molecular aspects
   4. How drugs act: cellular aspects excitation, contraction and secretion
   5. Biopharmaceuticals and gene therapy
   6. Cell proliferation, apoptosis, repair and regeneration
   7. Cellular mechanisms: host defence
   8. Method and measurement in pharmacology
   9. Absorption and distribution of drugs
   10. Drug metabolism and elimination
   11. Pharmacokinetics
   12. Individual Variation, Pharmacogenomics and Personalised Medicine
3. Section 2. Chemical Mediators
   1. Chemical mediators and the autonomic nervous system
   2. Cholinergic transmission
   3. Noradrenergic transmission
   4. 5-Hydroxytryptamine and the Pharmacology of Migraine
   5. Purines
   6. Local Hormones 1: Histamin and the Biologically Active Lipids.
   7. Local Hormones 2: Peptides and Proteins
   8. Cannabinoids
   9. Nitric oxide and other gaseous mediators
4. Section 3. Drugs affecting major organ systems
   1. The heart
   2. The vascular system
   3. Atherosclerosis and lipid metabolism
   4. Haemostasis and thrombosis
   5. Haemopoietic system
   6. Anti-inflammatory and immunosuppressant drugs
   7. Skin
   8. Respiratory system
   9. The Kidney and urinary system
   10. The Gastrointestinal tract
   11. The control of blood glucose and drug treatment of diabetes mellitus
   12. Obesity
   13. The Pituitary and the adrenal cortex
   14. Thyroid
   15. The reproductive system
   16. Bone metabolism
5. Section 4. Nervous System
   1. Chemical transmission and drug action in the nervous system
   2. Amino acid transmitters
   3. Other transmitters and modulators
   4. Neurodegenerative diseases
   5. General anaesthetic agents
   6. Analgesic drugs
   7. Local anaesthetics and other drugs affecting sodium channels
   8. Anxiolytic and hypnotic drugs
   9. Antiepileptic drugs
   10. Antipsychotic drugs
   11. Antidepressant drugs
   12. CNS stimulants and psychotomimetic drugs
   13. Drug addiction, dependence and abuse
6. Section 5. Drugs used for the treatment of infections and cancer
   1. Basic principles of antimicrobial chemotherapy
   2. Antibacterial drugs
   3. Antiviral drugs
   4. Antifungal drugs
   5. Antiprotozoal drugs
   6. Anthelmintic drugs
   7. Anti-cancer drugs
7. Section 6. Special Topics
   1. Harmful effects of drugs
   2. Lifestyle drugs and drugs in sport
   3. Drug discovery and development

Authors Biography

James M. Ritter, DPhil FRCP FBPharmacolS FMedSci, Emeritus Professor of Clinical Pharmacology, King’s College London, and Medical Research Director, Quintiles, London, UK;

Rod J. Flower, PhD DSc FBPharmacolS FMedSci FRS, Professor, Biochemical Pharmacology, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London, UK and

Graeme Henderson, BSc PhD FBPharmacolS FSB, Professor of Pharmacology, University of Bristol, Bristol, UK