Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (5th Edition)

Description

Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.

Key Features

• Key updates reflect advances in PK/PD as related to clinical decision-making and drug research and development.
• An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
• Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
• More than 200 carefully written study questions, with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
• New and updated examples connect chapter content to real-world settings.
• Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
• eBook available for purchase. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more

Table of Contents

1. Preface vii
2. Nonproprietary and Brand Names of Drugs in Text and Illustrations xiii
3. Definition of Symbols xix
4. SECTION 1 BASIC CONSIDERATIONS 1
   1. CHAPTER 1 Therapeutic Relevance 3
   2. CHAPTER 2 Fundamental Concepts and T erminology 19
5. SECTION 2 EXPOSURE AND RESPONSE AFTER
   1. A SINGLE DOSE 51
   2. CHAPTER 3 Kinetics Following an Intravenous Bolus Dose 53
   3. CHAPTER 4 Membranes and Distribution 77
   4. CHAPTER 5 Elimination 119
   5. CHAPTER 6 Kinetics Following an Extravascular Dose 169
   6. CHAPTER 7 Absorption 197
   7. CHAPTER 8 Response 233
6. SECTION 3 THERAPEUTIC REGIMENS 265
   1. CHAPTER 9 Therapeutic W indow 267
   2. CHAPTER 10 Constant-Rate Input 283
   3. CHAPTER 11 Multiple-Dose Regimens 319
7. SECTION 4 INDIVIDUALIZATION 359
   1. CHAPTER 12 V ariability 361
   2. CHAPTER 13 Genetics 393
   3. CHAPTER 14 Age, W eight, and Gender 411
   4. CHAPTER 15 Disease 443
   5. CHAPTER 16 Nonlinearities 491
   6. CHAPTER 17 Drug Interactions 531
   7. CHAPTER 18 Initiating and Managing Therapy 577
8. SECTION 5 SUPPLEMENTAL TOPICS 611
   1. CHAPTER 19 Distribution Kinetics 613
   2. CHAPTER 20 Metabolites and Drug Response 657
   3. CONTENTS xii Contents
   4. CHAPTER 21 Protein Drugs 687
   5. CHAPTER 22 Prediction and Refinement of Human Kinetics from
   6. In Vitro, Preclinical, and Early Clinical Data 731
   7. APPENDICES 759
   8. APPENDIX A Assessment of AUC 759
   9. APPENDIX B Ionization and the pH Partition Hypothesis 763
   10. APPENDIX C Distribution of Drugs Extensively Bound to
   11. Plasma Proteins 767
   12. APPENDIX D Plasma-to-Blood Concentration Ratio 775
   13. APPENDIX E W ell-Stirred Model of Hepatic Clearance 777
   14. APPENDIX F Absorption Kinetics 781
   15. APPENDIX G W agner -Nelson Method 785
   16. APPENDIX H Mean Residence T ime 789
   17. APPENDIX I Amount of Drug in Body on Accumulation
   18. to Plateau 795
   19. APPENDIX J Introduction to MS Excel Simulations 799
   20. APPENDIX K Answers to Study Problems 805
   21. Index 903

Authors Biography

Hartmut Derendorf Ph.D

Stephan Schmidt Ph.D