Toxicologic Pathology for Non-Pathologists

Description

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances.

Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

Table of Contents

1. Introduction to Toxicologic Pathology – George A. Parker
2. The Pathology Report, Peer Review, and Pathology Working Group – Ted A. Birkebak, Peter C. Mann
3. Routine and Special Techniques in Toxicologic Pathology – amela Blackshear, Erica Carroll, Sasmita Mishra, Matthew Renninger, Arun Tatiparthi
4. Pathology of the Liver and Gallbladder – Robert R. Maronpot, David E. Malarkey
5. Pathology of the Gastrointestinal Tract and Exocrine Pancreas – Mark J. Hoenerhoff, Arun Kumar R. Pandiri
6. Pathology of the Urinary System – Kendall S. Frazier
7. Pathology of the Nervous System – Juliana S. Lee, Sarah D. Cramer, Mark T. Butt
8. Pathology of the Cardiovascular System – Joshua H. Decker, Radhakrishna Sura, Paul W. Snyder
9. Pathology of the Respiratory System – Jack R. Harkema, James G. Wagner
10. Pathology of the Lymphoid System – Tracey L. Papenfuss, Marlon C. Rebelatto, Brad Bolon
11. Pathology of the Male and Female Reproductive System and Mammary Gland – Justin D. Vidal
12. Pathology of the Integumentary System – Kelly L. Diegel, Lars Mecklenburg, Lydia Andrews-Jones, David F. Adams
13. Pathology of the Endocrine System – Brent E. Walling, Thomas J. Rosol
14. Pathology of Bone, Skeletal Muscle, and Tooth – Stacey L. Fossey, D. Greg Hall, Andrew W. Suttie, Martin Guillot, Aurore Varela
15. Pathology of the Eye – Leandro B. C. Teixeira
16. Pathology of the Ear – Kenneth A. Schafer
17. Principles of Toxicologic Clinical Pathology – Adam Aulbach, Laura Cregar
18. Carcinogenicity – Paul Howroyd
19. Pathology of Juvenile Animals – Catherine A. Picut, Amera K. Remick
20. Non-mammalian Laboratory Species: Fish, Frogs, and Beyond – Shannon M. Wallace, Jeffrey C. Wolf
21. Correction to: Pathology of the Integumentary System – Kelly L. Diegel, Lars Mecklenburg, Lydia Andrews-Jones, David F. Adams

Editors Biography

Thomas J. Steinbach DVM, DACVP, DABT (Experimental Pathology Laboratories, Inc., Research Triangle Park, NC, USA) and

Daniel J. Patrick DVM, DACVP, DABT (Charles River Laboratories, Inc., Mattawan, MI, USA) have worked for numerous years to help organize the successful “Pathology for Non-Pathologists” short course, created with the support of the American College of Toxicology (ACT) and Society of Toxicologic Pathology (STP), upon which this book is based.

Mary Ellen Cosenza PhD, DABT, RAC, ATS (MEC Regulatory & Toxicology Consulting, LLC, Moorpark, CA, USA) was an inaugural committee member of this short course and remains a highly respected member of the community at large.