Understanding Radiation Biology: From Dna Damage To Cancer And Radiation Risk

Description

This book provides a qualitative and quantitative exploration of the action of radiation on living matter which leads to a complete and coherent interpretation of radiation biology. It takes readers from radiation-induced molecular damage in the nucleus of the cell and links this damage to cellular effects such as cell killing, chromosome aberrations and mutations before exploring organ damage, organism lethality and cancer induction. It also deals with radiological protection concepts and the difficulties of predicting the dose–effect relationship for low-dose and dose rate radiation risk. The book ends with separate chapters dealing with the effects of UV light exposure and risk classification of chemical mutagens, both of which are derived by logical extensions of the radiation model. This book will provide the basic foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, radiological protection, medicine, radiology and radiography.

Key Features

• Presents a comprehensive insight into radiation action on living matter
• Contains important implications for radiological protection and regulations
• Provides analytical methods for applications in radiotherapy

Table of Contents

1. PART I: Ionising Radiation Effects.
   1. 1. The Molecular Model and DNA Double Strand Breaks.
   2. 2. The Molecular Model for Cellular Effects.
   3. 3. The Link from Molecular Lesion to Cellular Effects.
   4. 4. DNA Double Strand Breaks and Chromosomal Aberrations.
   5. 5. The Effect of Dose Rate, Fractionation and Post-Irradiation Repair.
   6. 6. Radiation Quality.
   7. 7. Radiation-Induced Cancer.
   8. 8. Radiation-Induced Lethality.
   9. 9 Radiological Protection.
2. PART II: Ultraviolet Light Effects.
   1. 10. The Molecular Model for the Cytotoxic Action of UV Light.
3. PART III: Genotoxicology.
   1. 11. An Assessment of the Risk of Chemical Mutagens.

Author Biography

Dr. K. H. Chadwick, now retired, worked as a research scientist in the Netherlands before moving to Belgium to manage research contracts on radiation biological effects in the Euratom Radiation Protection Research Programme of the European Commission in Brussels. He also served on the editorial board of the Journal for Radiological Protection for 10 years and is a fellow of the Institute of Physics (FInst P) and the Society for Radiological Protection (FSRP).