Williams Hematology (9th Edition)

Description

The world’s most highly regarded reference text on the mechanisms and clinical management of blood diseases

A Doody’s Core Title for 2020!

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields.

The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis.

Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Table of Contents

1. Initial approach to the patient: History and physical examination
2. Examination of blood cells
3. Examination of the marrow
4. Consultative Hematology
5. Structure of the marrow and hematopoietic microenvironment
6. The organization and structure of lymphoid tissues
7. Hematology of the fetus and newborn
8. Hematology during pregnancy
9. Hematology in older persons
10. Genetic principles
11. Genomics
12. Epigenetics
13. Cytogenetic and Genetic Abnormalities
14. Metabolism of Hematological Neoplastic Cells
15. Apoptosis and Autophagy
16. Cell cycle regulation and hematological disorders
17. Signal transduction pathways
18. Hematopoietic stem cells, progenitors, and cytokines
19. The inflammatory response
20. Innate immunity
21. Adaptive immunity
22. Pharmacology and toxicity of antineoplastic drugs
23. Hematopoietic stem cell transplantation
24. Treatment of infections in the immunocompromised host
25. Antithrombotic therapy
26. Immune cell therapy
27. Vaccine therapy
28. Therapeutic apheresis: indications, efficacy, and complications
29. Gene transfer for therapy
30. Regenerative Medicine: Multipotential cell therapy for tissue replacement
31. Structure and Composition of the Erythrocyte
32. Absorb former 30 Composition of Erythrocyte.
33. Erythropoiesis
34. Erythrocytes turnover
35. Clinical manifestations and classification of erythrocyte disorders
36. Aplastic anemia
37. Pure red cell aplasia
38. Anemia of chronic disease
39. Erythropoietic effects of endocrine disorders
40. The congenital dyserythropoietic anemias
41. Paroxysmal nocturnal hemoglobinuria
42. Folate, cobalamin and megaloblastic anemias
43. Iron Metabolism
44. Iron deficiency and overload
45. Anemia resulting from other nutritional deficiencies

Authors Biography

Kenneth Kaushansky, MD (Stony Brook, NY) is Senior Vice President, Health Sciences and Dean of the School of Medicine, Stony Brook University.

Marshall A. Lichtman, MD (Rochester, NY) is Professor of Medicine and of Biochemistry and Biophysics, University of Rochester Medical Center.

Josef T. Prchal, MD (Salt Lake City, UT, and Prague, Czech Republic) is Professor of Medicine, Pathology, and Genetics, Hematology Division of the University of Utah, and Department of Pathophysiology, First Faculty of Medicine, Charles University in Prague.

Marcel M. Levi, MD, PhD (Amsterdam, The Netherlands) is Chairman of the Department of Medicine at the Academic Medical Center, University of Amsterdam.

Oliver W. Press, MD, PhD (Seattle, WA) is Member and Penny E. Petersen Endowed Chair of Lymphoma Research, Fred Hutchinson Cancer Research Center, Professor of Medicine at the University of Washington.

Linda J. Burns, MD (Minneapolis, MN) is Vice President and Medical Director, Health Services Research at National Marrow Donor Program/Be The Match.

Michael A. Caligiuri, MD (Columbus, OH) is Director, Comprehensive Cancer Center, CEO, James Cancer Hospital & Solove Research Institute, JL Marakas Nationwide Insurance Enterprise Foundation Chair of Cancer Research, The Ohio State University.

Marshall Lichtman, M.D. Professor of Medicine, University of Rochester School of Medicine, Rochester, NY

Professor of Medicine, Pathology, and Genetics Hematology Division University of Utah Salt Lake City, Utah Department of Pathophysiology First Faculty of Medicine Charles University in Prague Czech Republic