Engineering 3D Tissue Test Systems

Description

Engineering 3D Tissue Test Systems provides an introduction to, and unique coverage of, a rapidly evolving area in biomaterials engineering. It reveals the current and future research responses, the current and future diagnostic applications, and provides a comprehensive overview to foster innovation. It offers insight into the importance of 3D systems and their use as benchtop models, spanning applications from basic scientific research to clinical diagnostics. Methods and limitations of building 3D tissue structures are evaluated, with attention given to the cellular, polymeric, and fabrication instrumentation components.

The book covers the important aspects of polymeric tissue test systems, highlighting the needs and constraints of the industry, and includes a chapter on regulatory and pricing issues.

Table of Contents

1. Preface
2. Acknowledgments
3. Editors
4. Contributors
5. Section I: Biofabrication Considerations
   1. Chapter 1 Introduction to 3D Test Systems
   2. Chapter 2 Biofabrication
   3. Chapter 3 Bioreactor Instrumentation and Control for 3D Cellular and Tissue Systems
   4. Chapter 4 Control of 3D Environment: Redesign of the Flow Loop Bioreactor to Control Mitral Valve Regurgitation
   5. Chapter 5 Nipple and Breast Construction: In Vitro and In Vivo Assessment
   6. Chapter 6 3D Cancer Spheroid Biofabrication Using Thermal Inkjet-Based Bioprinting for Rapid Screening
6. Section II: Materials Considerations
   1. Chapter 7 Control Testing and Effect of Manufacturing Parameters on the Biocompatibility of Polypropylene Mesh Implants
   2. Chapter 8 Scaffolds for 3D Model Systems in Bone Regenerative Engineering
   3. Chapter 9 Engineered Composites for 3D Mammary Tissue Systems
   4. Chapter 10 Mineralized 3D Culture Systems for Studying Bone Metastatic Breast Cancer
   5. Chapter 11 Design Considerations for 3D Cardiovascular Tissue Scaffolds
7. Section III: Biological Considerations
   1. Chapter 12 Pro- and Anti-Inflammatory Cytokine Signaling within 3D Tissue Models
   2. Chapter 13 Cell–Cell Communications through Gap Junctions and Cancer in 3D Systems
   3. Chapter 14 Advances in Breast Stem Cell Knowledge through 3D Systems
   4. Chapter 15 Shape Matters: Understanding the Breast through 3D Tissue Culture Models
   5. Chapter 16 Cells and Tissue Structures in Cardiovascular 3D Tissue Systems
   6. Chapter 17 Signaling and Architectural Cues Necessary for 3D Diabetic Tissue Models
   7. Chapter 18 Optimizing 3D Models of Engineered Skeletal Muscle
   8. Chapter 19 Recapitulating the Microenvironment of Glioblastoma Multiforme Using 3D Tissue Culture Models
8. Section IV: Business Considerations
   1. Chapter 20 Bringing Regenerative Medicine to Patients: The Coverage, Coding, and Reimbursement Processes
9. Index

Editor(s) Description

Karen J. L. Burg earned a B.S. in chemical engineering with a minor in biochemical engineering from North Carolina State University, an M.S. in bioengineering from Clemson University, and a Ph.D. in bioengineering with a minor in experimental statistics from Clemson University. She completed a tissue engineering postdoctoral research fellowship at Carolinas Medical Center in Charlotte, North Carolina, later serving as Clemson University Interim Vice Provost for Research & Innovation, Clemson University Interim Vice Provost and Dean of the Graduate School, and Kansas State University Vice President for Research.

Didier Dréau earned a B.S. in physiology and cell biology from Rennes I University (Rennes, France), an M.S. in Molecular and Cell Biology from Blaise Pascal University (Clermont-Ferrand, France) and a Ph.D. in Biochemistry, Molecular and Cell Biology with emphasis on Immunology from the Ecole Nationale Supérieure Agronomique (ENSA) de Rennes (France). Dr. Dréau, a member of the American Association for Cancer Research, serves on multiple granting agency review panels along with scientific journal editorial boards.

Timothy Burg earned a B.S. in Electrical Engineering from the University of Cincinnati and an M.S. and Ph.D. in electrical engineering from Clemson University. He is currently Professor of Veterinary Biosciences & Diagnostic Imaging in the University of Georgia College of Veterinary Medicine and Director of the University of Georgia Office of Science, Technology, Engineering and Mathematics Education.