Jawetz Melnick & Adelbergs Medical Microbiology (27th Edition) | KitaabNow

Jawetz Melnick & Adelbergs Medical Microbiology (27th Edition)

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  • Authors: Karen C. Carroll, Stefan Riedel, Stephen A. Morse, Timothy A. Mietzner, Steve Miller
  • ISBN: 9781259255342
  • Publisher: McGraw Hill Education
  • Edition: 27th
  • Publication Date: January 1, 2016
  • Format: Paperback – 880 pages
  • Language: English

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Understand the clinically relevant aspects of microbiology with this student-acclaimed, full-color review — bolstered by case studies and hundreds of USMLE®- style review questions

Since 1954, Jawetz, Melnick & Adelberg’s Medical Microbiology has been hailed by students, instructors, and clinicians as the single-best resource for understanding the roles microorganisms play in human health and illness.

Concise and fully up to date, this trusted classic links fundamental principles with the diagnosis and treatment of microbial infections. Along with brief descriptions of each organism, you will find vital perspectives on pathogenesis, diagnostic laboratory tests, clinical findings, treatment, and epidemiology. The book also includes an entire chapter of case studies that focuses on differential diagnosis and management of microbial infections.

Here’s why Jawetz, Melnick & Adelberg’s Medical Microbiology is essential for USMLE® review: 

  • 640+ USMLE-style review questions
  • 350+ illustrations
  • 140+ tables
  • 22 case studies to sharpen your differential diagnosis and management skills
  • An easy-to-access list of medically important microorganisms
  • Coverage that reflects the latest techniques in laboratory and diagnostic technologies
  • Full-color images and micrographs
  • Chapter-ending summaries
  • Chapter concept checks

Jawetz, Melnick & Adelberg’s Medical Microbiology, effectively introduces you to basic clinical microbiology through the fields of bacteriology, mycology, and parasitology, giving you a thorough yet understandable review of the discipline. Begin your review with it and see why there is nothing as time tested or effective.

Table of Contents
  1. Preface
  2. Section I Fundamentals of Microbiology
    1. The Science of Microbiology
      1. Introduction
      2. Biologic Principles Illustrated by Microbiology
      3. Viruses
      4. Prions
      5. Prokaryotes
      6. Protists
      7. Chapter Summary
      8. Review Questions
    2. Cell Structure
      1. Optical Methods
      2. Eukaryotic Cell Structure
      3. Prokaryotic Cell Structure
      4. Staining
      5. Morphologic Changes During Growth
      6. Chapter Summary
      7. Review Questions
    3. Classification of Bacteria
      1. Taxonomy—The Vocabulary of Medical Microbiology
      2. Criteria for Identification of Bacteria
      3. Classification Systems
      4. Description of the Major Categories and Groups of Bacteria
      5. Nonculture Methods for the Identification of Pathogenic Microorganisms
      6. Updates to Taxonomic Changes
      7. Objectives
      8. Review Questions
    4. Growth, Survival, and Death of Microorganisms
      1. Survival of Microorganisms in the Natural Environment
      2. The Meaning of Growth
      3. Exponential Growth
      4. The Growth Curve in Batch Culture
      5. Maintenance of Cells in the Exponential Phase
      6. Growth in Biofilms
      7. Definition and Measurement of Death
      8. Environmental Control of Microbial Growth
      9. Strategies to Control Bacteria at the Environmental Level
      10. General Mechanisms of Biocide Action
      11. Specific Actions of Selected Biocides
      12. Relationship of Biocide Concentration and Time on Antimicrobial Killing
      13. Summary
      14. Key Concepts
      15. Review Questions
    5. Cultivation of Microorganisms
      1. Requirements for Growth
      2. Sources of Metabolic Energy
      3. Nutrition
      4. Environmental Factors Affecting Growth
      5. Cultivation Methods
      6. Chapter Summary
      7. Review Questions
    6. Microbial Metabolism
      1. Role of Metabolism in Biosynthesis and Growth
      2. Focal Metabolites and Their Interconversion
      3. Assimilatory Pathways
      4. Biosynthetic Pathways
      5. Patterns of Microbial Energy-Yielding Metabolism
      6. Regulation of Metabolic Pathways
      7. Chapter Summary
      8. Review Questions
    7. Microbial Genetics
      1. Nucleic Acids and Their Organization in Eukaryotic, Prokaryotic, and Viral Genomes
      2. Replication
      3. Transfer of DNA
      4. Mutation and Gene Rearrangement
      5. Gene Expression
      6. Genetic Engineering
      7. Characterization of Cloned DNA
      8. Site-Directed Mutagenesis
      9. Analysis of DNA, RNA, or Protein-Expressing Clones
      10. Manipulation of Cloned DNA
      11. Chapter Summary
      12. Review Questions
  3. Section II Immunology
    1. Immunology
      1. Overview
      2. Innate Immunity
      3. Adaptive Immunity
      4. Complement
      5. Cytokines
      6. Microbiome and Immune System
      7. Hypersensitivity
      8. Defects of the Immune Response
      9. Tumor Immunology
      10. Clinical Immunology Laboratory (Diagnostic Testing)
      11. Chapter Summary
      12. Review Questions
  4. Section III Bacteriology
    1. Pathogenesis of Bacterial Infection
      1. Identifying Bacteria That Cause Disease
      2. Transmission of Infection
      3. The Infectious Process
      4. Genomics and Bacterial Pathogenicity
      5. Regulation of Bacterial Virulence Factors
      6. Bacterial Virulence Factors
      7. The Damage-Response Framework—A New Paradigm of Microbial Virulence and Pathogenicity
      8. Chapter Summary
      9. Review Questions
    2. Normal Human Microbiota
      1. Human Microbiome Project
      2. Role of the Resident Microbiota
      3. Normal Microbiota of the Skin
      4. Normal Microbiota of the Mouth and Upper Respiratory Tract
      5. Normal Microbiota of the Urethra
      6. Normal Microbiota of the Vagina
      7. Normal Microbiota of the Placenta and Uterus
      8. Normal Microbiota of the Conjunctiva
      9. Chapter Summary
      10. Review Questions
    3. Spore-Forming Gram-Positive Bacilli: Bacillus and Clostridium Species
      1. Bacillus species
      2. Bacillus anthracis
      3. Bacillus cereus
      4. Clostridium species
      5. Clostridium botulinum
      6. Clostridium tetani
      7. Clostridia That Produce Invasive Infections
      8. Clostridium difficile and Diarrheal Disease
      9. Review Questions
    4. Aerobic Non–Spore-Forming Gram-Positive Bacilli: Corynebacterium, Listeria, Erysipelothrix, Nocardia, and Related Pathogens
      1. Corynebacterium diphtheriae
      2. Other Coryneform Bacteria
      3. Listeria monocytogenes
      4. Erysipelothrix rhusiopathiae
      5. Rhodococcus equi
      6. Nocardiosis
      7. Review Questions
    5. The Staphylococci
      1. Chapter Summary
      2. Review Questions
    6. The Streptococci, Enterococci, and Related Genera
      1. Classification of Streptococci
      2. Streptococci, Enterococci, and Related Genera of Particular Medical Interest
      3. Streptococcus pyogenes
      4. Streptococcus agalactiae
      5. Groups C and G
      6. Group D Streptococci
      7. Streptococcus anginosus Group
      8. Groups E, F, G, H, and K–U Streptococci
      9. Viridans Streptococci
      10. Nutritionally Variant Streptococci
      11. Peptostreptococcus and Related Genera
      12. Streptococcus pneumoniae
      13. Enterococci
      14. Other Catalase-Negative Gram-Positive Cocci
      15. Review Questions
    7. Enteric Gram-Negative Rods (Enterobacteriaceae)
      1. Classification
      2. Diseases Caused by Enterobacteriaceae Other Than Salmonella and Shigella
      3. The Shigellae
      4. The Salmonellae
      5. Chapter Summary
      6. Review Questions
      7. 16. Pseudomonas, Acinetobacter, Burkholderia, and Stenotrophomonas
      8. The Pseudomonad Group
      9. Pseudomonas aeruginosa
      10. Burkholderia pseudomallei and Burkholderia mallei
      11. Burkholderia cepacia Complex
      12. Stenotrophomonas maltophilia
      13. Acinetobacter
      14. Chapter Summary
      15. Review Questions
    8. Vibrio, Aeromonas, Campylobacter, and Helicobacter
      1. The Vibrios
      2. Vibrio cholerae
      3. Vibrio parahaemolyticus and Vibrio vulnificus
      4. Aeromonas species
      5. Campylobacter
      6. Campylobacter jejuni
      7. Helicobacter pylori
      8. Chapter Summary
      9. Review Questions
    9. Haemophilus, Bordetella, Brucella, and Francisella
      1. The Haemophilus species
      2. Haemophilus influenzae
      3. Haemophilus aegypticus
      4. Aggregatibacter aphrophilus
      5. Haemophilus ducreyi
      6. Other Haemophilus Species
      7. The Bordetellae
      8. Bordetella pertussis
      9. Bordetella parapertussis
      10. Bordetella bronchiseptica
      11. Francisella tularensis and Tularemia
      12. Review Questions
    10. Yersinia and Pasteurella
      1. Yersinia pestis and Plague
      2. Yersinia enterocolitica and Yersinia pseudotuberculosis
      3. Pasteurella multocida
      4. Chapter Summary
      5. Review Questions
    11. The Neisseriae
      1. Neisseria gonorrhoeae
      2. Neisseria meningitidis
      3. Other Neisseriae
      4. Chapter Summary
      5. Review Questions
    12. Infections Caused by Anaerobic Bacteria
      1. Physiology and Growth Conditions for Anaerobes
      2. Anaerobic Bacteria Found in Human Infections
      3. Bacteria That Cause Vaginosis
      4. Gardnerella vaginalis
      5. Pathogenesis of Anaerobic Infections
      6. The Polymicrobial Nature of Anaerobic Infections
      7. Diagnosis of Anaerobic Infections
      8. Treatment of Anaerobic Infections
      9. Chapter Summary
      10. Review Questions
    13. Legionella, Bartonella, and Unusual Bacterial Pathogens
      1. Legionella pneumophila and Other Legionellae
      2. Bartonella
      3. Streptobacillus moniliformis
      4. Whipple Disease
      5. Review Questions
      6. 23. Mycobacteria
      7. Mycobacterium tuberculosis
      8. Other Mycobacterium
      9. Mycobacterium leprae
      10. Review Questions
    14. Spirochetes: Treponema, Borrelia, and Leptospira
      1. Treponema pallidum and Syphilis
      2. Borrelia
      3. Borrelia species and Relapsing Fever
      4. Borrelia burgdorferi and Lyme Disease
      5. Leptospira and Leptospirosis
      6. Chapter Summary
      7. Review Questions
    15. Mycoplasmas and Cell Wall–Defective Bacteria
      1. Mycoplasmas
      2. Mycoplasma pneumoniae and Atypical Pneumonias
      3. Mycoplasma hominis
      4. Ureaplasma urealyticum
      5. Mycoplasma genitalium
      6. Chapter Summary
      7. Review Questions
    16. Rickettsia and Related Genera
      1. General
      2. Rickettsia and Orientia
      3. Ehrlichia and Anaplasma
      4. Coxiella burnetii
      5. Review Questions
    17. Chlamydia spp.
      1. Chlamydia trachomatis Ocular, Genital, and Respiratory Infections
      2. Trachoma
      3. Chlamydia trachomatis Genital Infections and Inclusion Conjunctivitis
      4. Chlamydia trachomatis and Neonatal Pneumonia
      5. Lymphogranuloma Venereum
      6. Chlamydia pneumoniae and Respiratory Infections
      7. Chlamydia psittaci and Psittacosis
      8. Chapter Summary
      9. Review Questions
    18. Antimicrobial Chemotherapy
      1. Mechanisms of Action of Antimicrobial Drugs
      2. Selective Toxicity
      3. Inhibition of Cell Wall Synthesis
      4. Inhibition/Alteration of Cell Membrane Function
      5. Inhibition of Protein Synthesis
      6. Inhibition of Nucleic Acid Synthesis
      7. Resistance to Antimicrobial Drugs
      8. Origin of Drug Resistance
      9. Cross-Resistance
      10. Limitation of Drug Resistance
      11. Clinical Implications of Drug Resistance
      12. Antimicrobial Activity in vitro
      13. Factors Affecting Antimicrobial Activity
      14. Measurement of Antimicrobial Activity
      15. Antimicrobial Activity in vivo
      16. Drug–Pathogen Relationships
      17. Host–Pathogen Relationships
      18. Clinical Use of Antibiotics
      19. Selection of Antibiotics
      20. Dangers of Indiscriminate Use
      21. Antimicrobial Drugs Used in Combination
      22. Antimicrobial Chemoprophylaxis
      23. Antimicrobial Drugs For Systemic Administration
      24. Penicillins
      25. Cephalosporins
      26. Other ?-Lactam Drugs
      27. Tetracyclines
      28. Glycylcyclines
      29. Chloramphenicol
      30. Macrolides
      31. Clindamycin and Lincomycin
      32. Glycopeptides, Lipopeptides, Lipoglycopeptides
      33. Streptogramins
      34. Oxazolidinones
      35. Bacitracin
      36. Polymyxins
      37. Aminoglycosides
      38. Quinolones
      39. Sulfonamides and Trimethoprim
      40. Other Drugs With Specialized Uses
      41. Drugs Used Primarily to Treat Mycobacterial Infections
      42. Review Questions
  5. Section IV Virology
    1. General Properties of Viruses
      1. Terms and Definitions in Virology
      2. Evolutionary Origin of Viruses
      3. Classification of Viruses
      4. Principles of Virus Structure
      5. Chemical Composition of Viruses
      6. Cultivation and Detection of Viruses
      7. Purification and Identification of Viruses
      8. Laboratory Safety
      9. Reaction to Physical and Chemical Agents
      10. Replication of Viruses: An Overview
      11. Genetics of Animal Viruses
      12. Natural History (Ecology) and Modes of Transmission of Viruses
      13. Chapter Summary
      14. Review Questions
    2. Pathogenesis and Control of Viral Diseases
      1. Principles of Viral Diseases
      2. Pathogenesis of Viral Diseases
      3. Prevention and Treatment of Viral Infections
      4. Chapter Summary
      5. Review Questions
      6. 31. Parvoviruses
      7. Properties of Parvoviruses
      8. Parvovirus Infections in Humans
      9. Chapter Summary
      10. Review Questions
      11. 32. Adenoviruses
      12. Properties of Adenoviruses
      13. Adenovirus Infections in Humans
      14. Chapter Summary
      15. Review Questions
    3. Herpesviruses
      1. Properties of Herpesviruses
      2. Herpesvirus Infections in Humans
      3. Herpes Simplex Viruses
      4. Varicella-Zoster Virus
      5. Epstein-Barr Virus
      6. Cytomegalovirus
      7. Human Herpesvirus 6
      8. Human Herpesvirus 7
      9. Human Herpesvirus 8
      10. Herpes B Virus
      11. Chapter Summary
      12. Review Questions
    4. Poxviruses
      1. Properties of Poxviruses
      2. Poxvirus Infections in Humans: Vaccinia and Variola
      3. Monkeypox Infections
      4. Cowpox Infections
      5. Buffalopox Infections
      6. Orf Virus Infections
      7. Molluscum Contagiosum
      8. Tanapox and Yaba Monkey Tumor Poxvirus Infections
      9. Chapter Summary
      10. Review Questions
    5. Hepatitis Viruses
      1. Properties of Hepatitis Viruses
      2. Hepatitis Virus Infections in Humans
      3. Chapter Summary
      4. Review Questions
      5. 36. Picornaviruses (Enterovirus and Rhinovirus Groups)
      6. Properties of Picornaviruses
      7. Enterovirus Group
      8. Polioviruses
      9. Coxsackieviruses
      10. Other Enteroviruses
      11. Enteroviruses in the Environment
      12. Rhinoviruses
      13. Parechovirus Group
      14. Foot-and-Mouth Disease (Aphthovirus of Cattle)
      15. Chapter Summary
      16. Review Questions
    6. Reoviruses, Rotaviruses, and Caliciviruses
      1. Reoviruses and Rotaviruses
      2. Rotaviruses
      3. Reoviruses
      4. Orbiviruses and Coltiviruses
      5. Caliciviruses
      6. Astroviruses
      7. Chapter Summary
      8. Review Questions
    7. Arthropod-Borne and Rodent-Borne Viral Diseases
      1. Human Arbovirus Infections
      2. Togavirus and Flavivirus Encephalitis
      3. Yellow Fever Virus
      4. Dengue Virus
      5. Bunyavirus Encephalitis Viruses
      6. Sandfly Fever Virus
      7. Rift Valley Fever Virus
      8. Severe Fever with Thrombocytopenia Syndrome Virus
      9. Heartland Virus
      10. Colorado Tick Fever Virus
      11. Rodent-Borne Hemorrhagic Fevers
      12. Bunyavirus Diseases
      13. Arenavirus Diseases
      14. Filovirus Diseases
      15. Chapter Summary
      16. Review Questions
    8. Orthomyxoviruses (Influenza Viruses)
      1. Properties of Orthomyxoviruses
      2. Influenza Virus Infections in Humans
      3. Chapter Summary
      4. Review Questions
    9. Paramyxoviruses and Rubella Virus
      1. Properties of Paramyxoviruses
      2. Parainfluenza Virus Infections
      3. Respiratory Syncytial Virus Infections
      4. Human Metapneumovirus Infections
      5. Mumps Virus Infections
      6. Measles (Rubeola) Virus Infections
      7. Hendra Virus and Nipah Virus Infections
      8. Rubella (German Measles) Virus Infections
      9. Postnatal Rubella
      10. Congenital Rubella Syndrome
      11. Chapter Summary
      12. Review Questions
    10. Coronaviruses
      1. Properties of Coronaviruses
      2. Coronavirus Infections in Humans
      3. Chapter Summary
      4. Review Questions
      5. 42. Rabies, Slow Virus Infections, and Prion Diseases
      6. Rabies
      7. Borna Disease
      8. Slow Virus Infections and Prion Diseases
      9. Chapter Summary
      10. Review Questions
    11. Human Cancer Viruses
      1. General Features of Viral Carcinogenesis
      2. Molecular Mechanisms of Carcinogenesis
      3. Interactions of Tumor Viruses with Their Hosts
      4. RNA Tumor Viruses
      5. Hepatitis C Virus
      6. Retroviruses
      7. DNA Tumor Viruses
      8. Hepatitis B Virus
      9. Polyomaviruses
      10. Papillomaviruses
      11. Adenoviruses
      12. Herpesviruses
      13. Poxviruses
      14. How to Prove That a Virus Causes Human Cancer
      15. Chapter Summary
      16. Review Questions
    12. AIDS and Lentiviruses
      1. Properties of Lentiviruses
      2. HIV Infections in Humans
      3. Chapter Summary
      4. Review Questions
  6. Section V Mycology
    1. Medical Mycology
      1. General Properties, Virulence, and Classification of Pathogenic Fungi
      2. Laboratory Diagnosis of Mycoses
      3. Superficial Mycoses
      4. Cutaneous Mycoses
      5. Key Concepts: Superficial and Cutaneous Mycoses
      6. Subcutaneous Mycoses
      7. Sporotrichosis
      8. Chromoblastomycosis
      9. Phaeohyphomycosis
      10. Mycetoma
      11. Key Concepts: Subcutaneous Mycoses
      12. Endemic Mycoses
      13. Coccidioidomycosis
      14. Histoplasmosis
      15. Blastomycosis
      16. Paracoccidioidomycosis
      17. Key Concepts: Endemic Mycoses
      18. Opportunistic Mycoses
      19. Candidiasis
      20. Cryptococcosis
      21. Aspergillosis
      22. Mucormycosis
      23. Pneumocystis Pneumonia
      24. Penicilliosis
      25. Other Opportunistic Mycoses
      26. Emerging Pathogens
      27. Key Concepts: Opportunistic Mycoses
      28. Antifungal Prophylaxis
      29. Hypersensitivity to Fungi
      30. Mycotoxins
      31. Antifungal Chemotherapies
      32. Topical Antifungal Agents
      33. Key Concepts: Antifungal Chemotherapy
      34. Review Questions
  7. Section VI Parasitology
    1. Medical Parasitology
      1. Classification of Parasites
      2. Intestinal Protozoan Infections
      3. Giardia lamblia (Intestinal Flagellate)
      4. Entamoeba histolytica (Intestinal and Tissue Ameba)
      5. Other Intestinal Amebae
      6. Cryptosporidium (Intestinal Sporozoa)
      7. Cyclospora (Intestinal Sporozoa)
      8. Sexually Transmitted Protozoan Infection
      9. Trichomonas vaginalis (Genitourinary Flagellate)
      10. Blood and Tissue Protozoan Infections
      11. Blood Flagellates
      12. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense (Blood Flagellates)
      13. Trypanosoma cruzi (Blood Flagellate)
      14. Leishmania Species (Blood Flagellates)
      15. Entamoeba histolytica (Tissue Ameba)—See Intestinal Protozoan Infections Section
      16. Naegleria fowleri, Acanthamoeba castellanii, and Balamuthia mandrillaris (Free-Living Amebae)
      17. Plasmodium Species (Blood Sporozoa)
      18. Babesia microti (Blood Sporozoa)
      19. Toxoplasma gondii (Tissue Sporozoa)
      20. Microsporidia
      21. Intestinal Helminthic Infections
      22. Enterobius vermicularis (Pinworm—Intestinal Nematode)
      23. Trichuris trichiura (Whipworm—Intestinal Nematode)
      24. Ascaris lumbricoides (Human Roundworm—Intestinal Nematode)
      25. Ancylostoma duodenale and Necator americanus (Human Hookworms—Intestinal Nematode)
      26. Strongyloides stercoralis (Human Threadworm—Intestinal and Tissue Nematode)
      27. Trichinella spiralis (Intestinal and Tissue Nematode)
      28. Fasciolopsis buski (Giant Intestinal Fluke—Intestinal Trematode)
      29. Taenia saginata (Beef Tapeworm—Intestinal Cestode) and Taenia solium (Pork Tapeworm—Intestinal and Tissue Cestode)
      30. Diphyllobothrium latum (Broad Fish Tapeworm—Intestinal Cestode)
      31. Hymenolepis nana (Dwarf Tapeworm—Intestinal Cestode)
      32. Dipylidium caninum (Dog Tapeworm—Intestinal Cestode)
      33. Blood And Tissue Helminthic Infections
      34. Wuchereria bancrofti, Brugia malayi, and Brugia timori (Lymphatic Filariasis—Tissue Nematodes)
      35. Onchocerca volvulus (River Blindness—Tissue Nematode)
      36. Dracunculus medinensis (Guinea Worm—Tissue Nematode)
      37. Larva migrans (Zoonotic Larval Nematode Infections)
      38. Clonorchis Sinensis (Chinese Liver Fluke), Fasciola hepatica (Sheep Liver Fluke), and Paragonimus westermani (Lung Fluke)—Tissue Trematodes
      39. Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium (Blood Flukes)
      40. Tissue Cestode Infections (Caused by the Larval Stages)
      41. Taenia solium—Cysticercosis/Neurocysticercosis
      42. Echinococcus granulosus (Hydatid Cyst)
      43. Review Questions
  8. Section VII Diagnostic Medical Microbiology and Clinical Correlation
    1. Principles of Diagnostic Medical Microbiology
      1. Communication Between Physician and Laboratory
      2. Diagnosis of Bacterial and Fungal Infections
      3. The Importance of Normal Bacterial and Fungal Microbiota
      4. Laboratory Aids in the Selection of Antimicrobial Therapy
      5. Diagnosis of Infection by Anatomic Site
      6. Anaerobic Infections
      7. Diagnosis of Chlamydial Infections
      8. Diagnosis of Viral Infections
      9. Review Questions
    2. Cases and Clinical Correlations
      1. Central Nervous System
      2. Respiratory
      3. Heart
      4. Abdomen
      5. Urinary Tract
      6. Bone and Soft Tissue
      7. Sexually Transmitted Diseases
      8. Mycobacterium tuberculosis Infections
      9. Myocobacterium Avium Complex
      10. Infections in Transplant Patients
      11. Emerging Infections
  9. Index
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